Ipsilesional Mu Rhythm Desynchronization Correlates With Improvements in Affected Hand Grip Strength and Functional Connectivity in Sensorimotor Cortices Following BCI-FES Intervention for Upper Extremity in Stroke Survivors.
Ipsilesional Mu Rhythm Desynchronization Correlates With Improvements in Affected Hand Grip Strength and Functional Connectivity in Sensorimotor Cortices Following BCI-FES Intervention for Upper Extremity in Stroke Survivors.
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脑卒中幸存者上肢BCI-FES干预后，单侧Mu节律失同步与受影响的握力和感觉运动皮质功能连通性的改善相关
DOI：
10.3389/fnhum.2021.725645
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发表时间：
2021
影响因子：
2.9
通讯作者：
Prabhakaran V
中科院分区：
文献类型：
--
作者：
Remsik AB;Gjini K;Williams L Jr;van Kan PLE;Gloe S;Bjorklund E;Rivera CA;Romero S;Young BM;Nair VA;Caldera KE;Williams JC;Prabhakaran V
中风是导致长期上肢运动障碍的主要原因。目前的护理轨迹标准无法为中风幸存者提供足够的运动康复。最近的研究表明，脑机接口（BCI）设备的使用可以改善中风幸存者的运动功能，无论中风的严重程度和慢性程度如何，并且可能诱导和/或促进与运动康复相关的神经可塑性变化。目前正在进行的交叉对照试验 NCT02098265 的子分析首先检查，与休息相比，在受影响的手运动期间，大脑皮层感觉运动区域 [布罗德曼区 (BA) 1-7] 的同病 Mu 节律去同步化是否是局部的，并随握力强度的变化而变化。其次，我们通过测量被认为与运动动作和运动学习的电生理特征相关的大脑皮层感觉运动区域之间的孤立有效一致性（iCoh）的变化来检验BCI干预导致BA 1-7中频率特定的信息传输定向流（直接路径功能连接）变化的假设。 16 名患有右半球损伤（左手运动障碍）的中风幸存者样本接受了最长 18-30 小时的 BCI 干预。在干预期间记录脑电图，同时在基线和干预完成时评估运动功能和能力的结果测量。与休息时相比，受损手运动期间 Mu 节律的更大去同步化主要局限于同侧感觉运动皮层 (BA 1-7)。此外，BCI 干预后与干预前相比，同侧初级运动皮层 Mu 去同步化的增加与通过握力测量评估的手部功能的改善显着相关。此外，结果显示，在 BCI 干预期间，通过 iCoh 测量的因果信息流向同侧运动 (BA 4) 和同侧前运动皮层 (BA 6) 的方向发生了显着变化。在 Mu [8–12 Hz] 和 Beta [18–26 Hz] 频率范围内观察到从同病灶 BA 4 到同病灶 BA 6 的 iCoh 显着增加。总之，目前的结果表明运动能力和行为有所改善，并且与 BCI-FES 干预改善同侧半球和受损手的功能运动能力的观点是一致的。
Stroke is a leading cause of acquired long-term upper extremity motor disability. Current standard of care trajectories fail to deliver sufficient motor rehabilitation to stroke survivors. Recent research suggests that use of brain-computer interface (BCI) devices improves motor function in stroke survivors, regardless of stroke severity and chronicity, and may induce and/or facilitate neuroplastic changes associated with motor rehabilitation. The present sub analyses of ongoing crossover-controlled trial NCT02098265 examine first whether, during movements of the affected hand compared to rest, ipsilesional Mu rhythm desynchronization of cerebral cortical sensorimotor areas [Brodmann’s areas (BA) 1-7] is localized and tracks with changes in grip force strength. Secondly, we test the hypothesis that BCI intervention results in changes in frequency-specific directional flow of information transmission (direct path functional connectivity) in BA 1-7 by measuring changes in isolated effective coherence (iCoh) between cerebral cortical sensorimotor areas thought to relate to electrophysiological signatures of motor actions and motor learning. A sample of 16 stroke survivors with right hemisphere lesions (left hand motor impairment), received a maximum of 18–30 h of BCI intervention. Electroencephalograms were recorded during intervention sessions while outcome measures of motor function and capacity were assessed at baseline and completion of intervention. Greater desynchronization of Mu rhythm, during movements of the impaired hand compared to rest, were primarily localized to ipsilesional sensorimotor cortices (BA 1-7). In addition, increased Mu desynchronization in the ipsilesional primary motor cortex, Post vs. Pre BCI intervention, correlated significantly with improvements in hand function as assessed by grip force measurements. Moreover, the results show a significant change in the direction of causal information flow, as measured by iCoh, toward the ipsilesional motor (BA 4) and ipsilesional premotor cortices (BA 6) during BCI intervention. Significant iCoh increases from ipsilesional BA 4 to ipsilesional BA 6 were observed in both Mu [8–12 Hz] and Beta [18–26 Hz] frequency ranges. In summary, the present results are indicative of improvements in motor capacity and behavior, and they are consistent with the view that BCI-FES intervention improves functional motor capacity of the ipsilesional hemisphere and the impaired hand.
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DOI：
10.3389/fneng.2014.00030
发表时间：
2014
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Ang KK;Guan C;Phua KS;Wang C;Zhou L;Tang KY;Ephraim Joseph GJ;Kuah CW;Chua KS
通讯作者：
Chua KS
影响因子：
4.3
作者：
Mohanty R;Sinha AM;Remsik AB;Dodd KC;Young BM;Jacobson T;McMillan M;Thoma J;Advani H;Nair VA;Kang TJ;Caldera K;Edwards DF;Williams JC;Prabhakaran V
通讯作者：
Prabhakaran V
影响因子：
3.4
作者：
Mitra, PP;Pesaran, B
通讯作者：
Pesaran, B
影响因子：
1.5
作者：
Kim, TaeHoon;Kim, SeongSik;Lee, ByoungHee
通讯作者：
Lee, ByoungHee
影响因子：
4.3
作者：
Mazrooyisebdani, Mohsen;Nair, Veena A.;Prabhakaran, Vivek
通讯作者：
Prabhakaran, Vivek