Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.
Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.
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APPL2 基因变异与糖耐量正常的中国人群超重和肥胖有关
DOI：
10.1186/1471-2350-13-22
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发表时间：
2012-03-30
影响因子：
--
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Jiang S;Fang Q;Yu W;Zhang R;Hu C;Dong K;Bao Y;Wang C;Xiang K;Jia W
背景：APPL 1和APPL 2是两种接头蛋白，通过与肌细胞脂联素受体N端结合，介导脂联素信号转导。编码脂联素和脂联素受体的基因与胰岛素抵抗和肥胖风险有关，APPL 1的遗传变异与体脂分布有关。然而，APPL 2的遗传变异和代谢性状之间的关联仍然未知。在本研究中，我们的目的是测试APPL 2基因变异对肥胖的影响，在中国人群与正常glucose tolerance.Methods：我们基因型APPL 2在1,808非糖尿病受试者的6个单核苷酸多态性（SNPs）。超重和肥胖的定义是身体质量指数（BMI）。测量与肥胖相关的人体测量参数，包括身高、体重、腰围、臀围。结果：我们发现rs 2272495和rs 1107756与超重/肥胖有显著的相关性。rs 2272495 C等位基因和rs 1107756 T等位基因均增加超重和肥胖的风险（rs 2272495 OR 1.218，95%CI 1.047-1.416，p = 0.011; rs 1107756 OR 1.166，95%CI 1.014-1.341，p = 0.031）。在调整多重比较后，只有rs 2272495对超重/肥胖的影响仍然是显著的（经验p = 0.043）。此外，我们调查了这些SNPs对所有参与者肥胖相关数量性状的影响。在隐性模型下，rs 2272495与BMI（p = 0.015）、腰围（p = 0.006）、臀围（p = 0.025）以及WHR（p = 0.047）相关。结论：APPL 2基因多态性与中国糖耐量正常人群超重和肥胖相关。
Background:APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of adiponectin receptors in muscle cells. Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. However, the association between genetic variations of APPL2 and metabolic traits remains unknown. In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance.Methods:We genotyped six single nucleotide polymorphisms (SNPs) in APPL2 in 1,808 non-diabetic subjects. Overweight and obesity were defined by body mass index (BMI). Obesity-related anthropometric parameters were measured, including height, weight, waist circumference, hip circumference. BMI and waist-hip ratio (WHR) were calculated.Results:We found significant evidence of association with overweight/obesity for rs2272495 and rs1107756. rs2272495 C allele and rs1107756 T allele both conferred a higher risk of being overweight and obese (OR 1.218, 95% CI 1.047-1.416, p = 0.011 for rs2272495; OR 1.166, 95% CI 1.014-1.341, p = 0.031 for rs1107756). After adjusting multiple comparisons, only the effect of rs2272495 on overweight/obesity remained to be significant (empirical p = 0.043). Moreover, we investigated the effects of these SNPs on obesity-related quantitative traits in all participants. rs2272495 was associated with BMI (p = 0.015), waist circumference (p = 0.006), hip circumference (p = 0.025) as well as WHR (p = 0.047) under a recessive model. Similar associations were found for rs1107756 except for WHR.Conclusion:This study suggests that genetic variations in APPL2 are associated with overweight and obesity in Chinese population with normal glucose tolerance.
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