Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape.

Breath-Based Diagnosis of Infectious Diseases: A Review of the Current Landscape.
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呼吸为基础的传染病诊断:当前景观的回顾。

DOI:
10.1016/j.cll.2021.03.002
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发表时间:
2021-06
影响因子:
1.7
通讯作者:
Koo S
Koo S
中科院分区:
医学4区
文献类型:
--
作者:
Ghosh C;Leon A;Koshy S;Aloum O;Al-Jabawi Y;Ismail N;Weiss ZF;Koo S

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自古以来,呼吸就被认为是病理生理过程的诊断线索。古希腊医生描述了糖尿病患者的甜味和我们现在知道的肾病患者散发的鱼一样的气味。呼吸分析的现代时代开始于生物化学家Linus Pauling使用当时可用的方法描述了人类呼吸中挥发性有机化合物(VOC)的景观,发现这些VOC源自许多内源性生化过程,包括来自脂质氧化的醛和烷烃以及来自碳水化合物和脂肪酸代谢的酮2 -5。来自这些过程的气相代谢物和分解产物通过循环系统携带并通过肺迅速排出。
Breath has been proposed to hold diagnostic clues to pathophysiologic processes since ancient times. Ancient Greek physicians described a sweet smell in patients with diabetes and a fish-like odor emanating from patients with what we now know to be kidney disease1.The modern era of breath analysis started when biochemist Linus Pauling characterized the landscape of volatile organic compounds (VOCs) in human breath using methods available to him at the time, finding these VOCs to originate from numerous endogenous biochemical processes, including aldehydes and alkanes from lipid oxidation and ketones from carbohydrate and fatty acid metabolism2–5. Gas-phase metabolites and breakdown products originating from these processes are carried through the circulatory system and rapidly excreted through the lungs.
DOI: 10.1128/jcm.02838-12
发表时间: 2013-05-01
影响因子: 9.4
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