Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials.
Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials.
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DOI：
10.1002/acr.20519
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发表时间：
2011-09
影响因子：
4.7
通讯作者：
Gelber, Allan C.
中科院分区：
文献类型：
--
作者：
Juraschek, Stephen P.;Miller, Edgar R., III;Gelber, Allan C.
通过汇总已发表的随机对照试验（RCTs）的结果，评估维生素C补充剂对血清尿酸（SUA）的影响。通过系统检索确定的2,082篇出版物符合以下纳入标准：(1)以人类受试者为对象进行的随机对照试验；(2)报告的试验末SUA均值和方差；(3)口服维生素C补充组和同期对照组的研究设计；(4)试验时间不少于一周。纳入儿童或透析患者的试验被排除在外。两位研究者独立提取试验和参与者特征。采用随机效应模型汇总SUA效应，并采用逆方差加权。在MEDLINE、EMBASE和CENTRAL数据库中确定了13项随机对照试验。参与者总数为556人，维生素C的中位剂量为500 mg/d，试验规模为8至184人，研究持续时间中位数为30天。预处理SUA值为2.9 ~ 7.0 mg/dL （SI: 172.5 ~ 416.4 μmol/L）。这些试验的综合效果是SUA显著降低-0.35 mg/dL （95% CI: -0.66, -0.03; P = 0.032; SI: -20.8 μmol/L）。试验异质性显著（I2 = 77%; P < 0.01）。基于试验特征的亚组分析表明，在安慰剂对照的试验中，尿酸的降低幅度更大。总的来说，补充维生素C显著降低了SUA。未来的试验需要确定补充维生素C是否可以减少高尿酸血症或预防痛风的发生和复发。
To assess the effect of vitamin C supplementation on serum uric acid (SUA) by pooling the findings from published randomized, controlled trials (RCTs). A total of 2,082 publications identified through systematic search were subjected to the following inclusion criteria: (1) RCTs conducted on human subjects; (2) reported end-trial SUA means and variance; (3) study design with oral vitamin C supplementation and concurrent control groups; and (4) trial duration of at least one week. Trials that enrolled children or patients on dialysis were excluded. Two investigators independently abstracted trial and participant characteristics. SUA effects were pooled by random-effects models and weighted by inverse variance. Thirteen RCTs were identified in MEDLINE, EMBASE, and CENTRAL databases. The total number of participants was 556, median dose of vitamin C was 500 mg/d, trial size ranged from 8 to 184 participants, and median study duration was 30 days. Pretreatment SUA values ranged from 2.9 to 7.0 mg/dL (SI: 172.5 – 416.4 μmol/L). The combined effect of these trials was a significant reduction in SUA of -0.35 mg/dL (95% CI: -0.66, -0.03; P = 0.032; SI: -20.8 μmol/L). Trial heterogeneity was significant (I2 = 77%; P < 0.01). Subgroup analyses based on trial characteristics indicated larger reductions in uric acid in trials that were placebo-controlled. In aggregate, vitamin C supplementation significantly lowered SUA. Future trials are needed to determine whether vitamin C supplementation can reduce hyperuricemia or prevent incident and recurrent gout.
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影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
影响因子：
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作者：
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影响因子：
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作者：
Choi, Hyon K.;Gao, Xiang;Curhan, Gary
通讯作者：
Curhan, Gary
影响因子：
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作者：
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通讯作者：
Fox, Caroline S.
影响因子：
158.5
作者：
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通讯作者：
Dodek, A