Vitamin C intake and the risk of gout in men: a prospective study.
Vitamin C intake and the risk of gout in men: a prospective study.
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维生素C摄入量和男性痛风的风险：一项前瞻性研究。
DOI：
10.1001/archinternmed.2008.606
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发表时间：
2009-03-09
影响因子：
--
通讯作者：
Curhan, Gary
中科院分区：
文献类型：
--
作者：
Choi, Hyon K.;Gao, Xiang;Curhan, Gary
几项代谢研究和最近的一项双盲安慰剂对照随机试验表明，较高的维生素C摄入量显著降低了血清尿酸水平。然而，与痛风风险的关系尚不清楚。我们对46,994名无痛风病史的男性参与者进行了长达20年(1986-2006年)的前瞻性研究，考察了维生素C摄入量与痛风发病风险之间的关系。我们使用补充问卷来确定美国风湿病学会的痛风标准。通过有效问卷每四年评估一次维生素C摄入量。在20年的随访中，我们记录了1,317例确诊的痛风病例。与维生素C摄入量为250 mg/天的男性相比，维生素C摄入量为500-999 mg/天的痛风的多变量相对危险度为0.83(95%可信区间为0.71-0.97)，1,000-1,499 mg/天为0.66(0.52-0.86)，≥为1500 mg/天为0.55(0.38-0.80)(P为Trend<；0.001)。每日总维生素C摄入量每增加500毫克的多变量相对危险度为0.83(95%CI，0.77~0.90)。与不补充维生素C的男性相比，补充维生素C 1,000-1,499 mg/d和≥1500 mg/d痛风的多变量RR分别为0.66(95%CI，0.49~0.88)和0.55(0.36~0.86)(P为Trend<；0.001)。维生素C摄入量越高，患痛风的风险越低。补充维生素C摄入可能对预防痛风有益。
Several metabolic studies and a recent double-blinded placebo-controlled randomized trial have shown that higher vitamin C intake significantly reduces serum uric acid levels. Yet, the relation with the risk of gout is unknown. We prospectively examined over a 20-year period (1986–2006) the relation between vitamin C intake and the risk of incident gout in 46,994 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. Vitamin C intake was assessed every four years through validated questionnaires. During the 20 years of follow-up, we documented 1,317 confirmed incident cases of gout. Compared with men with vitamin C intake < 250mg/day, the multivariate relative risk (RR) of gout was 0.83 (95% confidence interval [CI], 0.71 to 0.97) for total vitamin C intake 500–999 mg/day, 0.66 (0.52 to 0.86) for 1,000–1,499 mg/day, and 0.55 (0.38 to 0.80) for ≥ 1500 mg/day (P for trend < 0.001). The multivariate RR per 500mg increase in total daily vitamin C intake was 0.83 (95% CI, 0.77 to 0.90). Compared with men who did not use supplemental vitamin C, the multivariate RR of gout was 0.66 (95% CI, 0.49 to 0.88) for supplemental vitamin C intake 1,000–1,499 mg/day and 0.55 (0.36 to 0.86) for ≥ 1500 mg/day (P for trend < 0.001). Higher vitamin C intake is independently associated with a lower risk of gout. Supplemental vitamin C intake may be beneficial in the prevention of gout.
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DOI：
10.1002/art.22762
发表时间：
2007-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Choi, Hyon K.;Curhan, Gary
通讯作者：
Curhan, Gary
影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
影响因子：
5.9
作者：
BERGER, L;GERSON, CD;YU, TF
通讯作者：
YU, TF
影响因子：
7.2
作者：
ABBOTT, RD;BRAND, FN;CASTELLI, WP
通讯作者：
CASTELLI, WP
影响因子：
6.6
作者：
Curhan, GC;Willett, WC;Stampfer, MJ
通讯作者：
Stampfer, MJ