Pramipexole-induced disruption of behavioral processes fundamental to intertemporal choice.
Pramipexole-induced disruption of behavioral processes fundamental to intertemporal choice.
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普拉克索引起的对跨期选择至关重要的行为过程的破坏。
DOI：
10.1002/jeab.21
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发表时间：
2013
影响因子：
2.7
通讯作者：
Madden,GregoryJ
中科院分区：
文献类型：
--
作者：
Johnson,PatrickS;Stein,JeffreyS;Smits,RochelleR;Madden,GregoryJ
Evaluating the effects of presession drug administration on intertemporal choice in nonhumans is a useful approach for identifying compounds that promote impulsive behavior in clinical populations, such as those prescribed the dopamine agonist pramipexole (PPX). Based on the results of previous studies, it is unclear whether PPX increases rats' impulsive choice or attenuates aspects of stimulus control. The present study was designed to experimentally isolate behavioral processes fundamental to intertemporal choice and challenge them pharmacologically with PPX administration. In Experiment 1, the hypothesis that PPX increases impulsive choice as a result of enhanced sensitivity to reinforcer delays was tested and disconfirmed. That is, acute PPX diminished delay sensitivity in a manner consistent with disruption of stimulus control whereas repeated PPX had no effect on delay sensitivity. Experiments 2 and 3 elaborated upon this finding by examining the effects of repeated PPX on rats' discrimination of response–reinforcer contingencies and reinforcer amounts, respectively. Accuracy of both discriminations was reduced by PPX. Collectively these results provide no support for past studies that have suggested PPX increases impulsive choice. Instead, PPX impairs stimulus control over choice behavior. The behavioral approach adopted herein could be profitably integrated with genetic and other biobehavioral models to advance our understanding of impulsive behavior associated with drug administration.
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选择性多巴胺能化合物对延迟减少任务的影响。
影响因子：
1.6
作者：
Koffarnus MN;Newman AH;Grundt P;Rice KC;Woods JH
通讯作者：
Woods JH
DOI：
--
发表时间：
1958
期刊：
影响因子：
--
作者：
Dews Pb
通讯作者：
Dews Pb
影响因子：
8.6
作者：
Perez-Lloret, Santiago;Bondon-Guitton, Emmanuelle;Montastruc, Jean-Louis
通讯作者：
Montastruc, Jean-Louis
影响因子：
3.4
作者：
Boulougouris, Vasileios;Castane, Anna;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
2.3
作者：
Stanger, Catherine;Ryan, Stacy R.;Fu, Hongyun;Landes, Reid D.;Jones, Bryan A.;Bickel, Warren K.;Budney, Alan J.
通讯作者：
Budney, Alan J.