Monitoring angiogenesis noninvasively with near-infrared spectroscopy.
Monitoring angiogenesis noninvasively with near-infrared spectroscopy.
复制标题
使用近红外光谱无创监测血管生成。
DOI:
10.1117/1.3000431
复制
发表时间:
2008
影响因子:
3.5
通讯作者:
Shaw,RAnthony
中科院分区:
文献类型:
--
作者:
Dunn,JeffreyF;Zhang,Qiong;Wu,Ying;Srinivasan,Sathyanarayanan;Smith,MichaelR;Shaw,RAnthony
Near-infrared (NIR) spectroscopy is used to quantify cerebral blood volume (CBV) as a marker of angiogenesis (formation of new blood vessels). Rats are exposed to chronic hypoxia forat half atmospheric pressure to stimulate angiogenesis, and second-differential NIR spectroscopy is used to quantify total cerebral hemoglobin before and after angiogenesis. The cerebral hemoglobin (from broadband NIR spectroscopy), and the large vessel hemoglobin and hematocrit (from blood samples), are used to derive values for the calculation of CBV. The total hemoglobin in brain is(,) preacclimation and increases by 72% postacclimation. CBV is initiallyv/v and increases by 31% with acclimation. Each individual animal shows a measureable increase in CBV. This study indicates that NIR broadband spectroscopy can be used for repeated measurements of CBV and can be applied as a noninvasive method to study angiogenesis.
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DOI:
--
发表时间:
1971
期刊:
Journal of Physiology
影响因子:
--
作者:
M. Peaker
通讯作者:
M. Peaker
DOI:
10.1083/jcb.40.2.305
发表时间:
1969-02
期刊:
The Journal of cell biology
影响因子:
--
作者:
Ernst SA;Ellis RA
通讯作者:
Ellis RA
DOI:
10.1016/0005-2736(67)90098-3
发表时间:
1967-01-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子:
--
作者:
ERNST, SA;GOERTEMI.CC;ELLIS, RA
通讯作者:
ELLIS, RA
DOI:
10.1073/pnas.79.19.6033
发表时间:
1982-01-01
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子:
--
作者:
MASON, RJ;WILLIAMS, MC;BERRY, LC
通讯作者:
BERRY, LC
影响因子:
3.6
作者:
Hossler Fe;Sarras Mp;Allen Er
通讯作者:
Allen Er