Anterior trunk muscle shows mix of axial and appendicular developmental patterns

Anterior trunk muscle shows mix of axial and appendicular developmental patterns
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前躯干肌肉显示出轴向和四肢发育模式的混合

DOI:
10.1002/dvdy.95
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发表时间:
2019
影响因子:
2.5
通讯作者:
Devoto, Stephen H.
Devoto, Stephen H.
中科院分区:
生物学3区
文献类型:
--
作者:
Sagarin, Kathleen A.;Redgrave, Anna C.;Mosimann, Christian;Burke, Ann C.;Devoto, Stephen H.

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研究背景躯干肌起源于近轴中胚层的体节。而轴向肌肉组织的体节内的发展,approximular肌肉的发展,肌肉前体迁移到侧板中胚层。肌肉桥接轴向和approximal systems的发展出现mixed.ResultsWe检查三个迁移肌肉前体衍生的肌肉在斑马鱼的发展:胸骨舌骨肌(SH),胸鳍(PF),和后hypaxial(PHM)肌肉。我们发现这三种肌肉的发育基因表达和成熟有一个从前到后的梯度。SH肌前体在迁移和分化之间表现出长时间的延迟,PF肌前体在分化中表现出中等延迟,而PHM肌前体在迁移和分化之间几乎没有延迟。使用谱系追踪,我们表明,侧板的贡献PHM肌肉是轻微的,不像其已知的广泛的贡献PF肌肉和缺乏在腹侧延伸轴musculation.ConclusionsWe建议,PHM的发展是一个迁移的肌肉模式和轴向肌肉发展模式之间的中间,其中PHM在其前体非常短的迁移之后分化,并且主要通过分化的肌纤维的伸长而变得更靠前。
BackgroundSkeletal muscle in the trunk derives from the somites, paired segments of paraxial mesoderm. Whereas axial musculature develops within the somite, appendicular muscle develops following migration of muscle precursors into lateral plate mesoderm. The development of muscles bridging axial and appendicular systems appears mixed.ResultsWe examine development of three migratory muscle precursor‐derived muscles in zebrafish: the sternohyoideus (SH), pectoral fin (PF), and posterior hypaxial (PHM) muscles. We show there is an anterior to posterior gradient to the developmental gene expression and maturation of these three muscles. SH muscle precursors exhibit a long delay between migration and differentiation, PF muscle precursors exhibit a moderate delay in differentiation, and PHM muscle precursors show virtually no delay between migration and differentiation. Using lineage tracing, we show that lateral plate contribution to the PHM muscle is minor, unlike its known extensive contribution to the PF muscle and absence in the ventral extension of axial musculature.ConclusionsWe propose that PHM development is intermediate between a migratory muscle mode and an axial muscle mode of development, wherein the PHM differentiates after a very short migration of its precursors and becomes more anterior primarily by elongation of differentiated muscle fibers.
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