Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.
Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.
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DOI：
10.1016/j.immuni.2017.10.021
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发表时间：
2017-11-21
期刊：
影响因子：
32.4
通讯作者：
Goodridge HS
中科院分区：
文献类型：
--
作者：
Yáñez A;Coetzee SG;Olsson A;Muench DE;Berman BP;Hazelett DJ;Salomonis N;Grimes HL;Goodridge HS
粒细胞-单核细胞祖细胞（GMP）和单核细胞-树突状细胞祖细胞（MDP）在体内平衡期间产生单核细胞，并响应感染期间增加的需求。两个祖细胞群体被认为是来自共同的骨髓祖细胞（CMP），并假定一个层次关系（CMP-GMP-MDP-单核细胞）的基础单核细胞分化。然而，在这里，我们证明小鼠MDP独立于GMP而由CMP产生，并且GMP和MDP通过相似但不同的单核细胞定向祖细胞产生单核细胞。GMP和MDP产生具有基因表达特征的经典（Ly 6Chi）单核细胞，所述基因表达特征由其来源定义并影响其功能。GMP产生了一个子集的“嗜中性粒细胞样”单核细胞，而MDP产生了一个子集的单核细胞，产生单核细胞衍生的树突状细胞。GMP和MDP也被独立动员，以在注射微生物组分后产生骨髓细胞类型的特定组合。因此，GMP和MDP分化的平衡在体内平衡期间和感染后形成骨髓细胞库。
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. Both progenitor populations are thought to derive from common myeloid progenitors (CMPs), and a hierarchical relationship (CMP-GMP-MDP-monocyte) is presumed to underlie monocyte differentiation. Here, however, we demonstrate that mouse MDPs arose from CMPs independently of GMPs, and that GMPs and MDPs produced monocytes via similar, but distinct, monocyte-committed progenitors. GMPs and MDPs yielded classical (Ly6Chi) monocytes with gene expression signatures that were defined by their origins and impacted their function. GMPs produced a subset of “neutrophil-like” monocytes, whereas MDPs gave rise to a subset of monocytes that yielded monocyte-derived dendritic cells. GMPs and MDPs were also independently mobilized to produce specific combinations of myeloid cell types following the injection of microbial components. Thus, the balance of GMP and MDP differentiation shapes the myeloid cell repertoire during homeostasis and following infection.
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DOI：
10.1084/jem.20030107
发表时间：
2003-07-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
D'Amico A;Wu L
通讯作者：
Wu L
影响因子：
64.8
作者：
Olsson, Andre;Venkatasubramanian, Meenakshi;Chaudhri, Viren K.;Aronow, Bruce J.;Salomonis, Nathan;Singh, Harinder;Grimes, H. Leighton
通讯作者：
Grimes, H. Leighton
影响因子：
32.4
作者：
Menezes, Shinelle;Melandri, Daisy;Anselmi, Giorgio;Perchet, Thibaut;Loschko, Jakob;Dubrot, Juan;Patel, Rajen;Gautier, Emmanuel L.;Hugues, Stephanie;Longhi, M. Paula;Henry, Jake Y.;Quezada, Sergio A.;Lauvau, Gregoire;Lennon-Dumenil, Ana-Maria;Gutierrez-Martinez, Enrique;Bessis, Alain;Gomez-Perdiguero, Elisa;Jacome-Galarza, Christian E.;Garner, Hannah;Geissmann, Frederic;Golub, Rachel;Nussenzweig, Michel C.;Guermonprez, Pierre
通讯作者：
Guermonprez, Pierre
影响因子：
--
作者：
Kotecha, Nikesh;Krutzik, Peter O;Irish, Jonathan M
通讯作者：
Irish, Jonathan M
影响因子：
100.3
作者：
Goodridge, Helen S.;Ahmed, S. Sohail;Wilson, Christopher B.
通讯作者：
Wilson, Christopher B.