Representation of negative motivational value in the primate lateral habenula.
Representation of negative motivational value in the primate lateral habenula.
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DOI：
10.1038/nn.2233
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发表时间：
2009-01
影响因子：
25
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Matsumoto, Masayuki;Hikosaka, Okihide
一个行为可能导致奖励或惩罚。因此，需要根据预期奖励和预期惩罚的价值来选择适当的行动。为了理解潜在的神经机制，我们在两种不同的环境下使用巴甫洛夫程序对猴子进行条件反射：一种是奖励，另一种是害怕惩罚。我们发现，在每种情况下，与最不愉快的事件相关的条件刺激（没有奖励或有惩罚）最强烈地激发了侧缰核神经元群。侧缰核神经元群也会因惩罚本身而兴奋，并因奖励本身而抑制，尤其是在它们难以预测的情况下。这些结果表明，侧缰有可能通过其对多巴胺能和血清素能系统的投射，自适应地控制寻求奖励和逃避惩罚的行为。
An action may lead to a reward or punishment. Therefore, an appropriate action needs to be chosen based on the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in which rewards were available, and another in which punishments were feared. We found that the population of lateral habenula neurons were most strongly excited by a conditioned stimulus associated with the most unpleasant event in each context: the absence of the reward or the presence of the punishment. The population of lateral habenula neurons were also excited by the punishment itself and inhibited by the reward itself, especially when they were less predictable. These results suggest that the lateral habenula has the potential to adaptively control both reward-seeking and punishment-avoidance behaviors, presumably through its projections to dopaminergic and serotonergic systems.
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