Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.
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DOI：
10.1084/jem.169.3.1169
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发表时间：
1989-03-01
影响因子：
15.3
通讯作者：
STEINMAN, RM
中科院分区：
文献类型：
--
作者：
ROMANI, N;KOIDE, S;CROWLEY, M;WITMERPACK, M;LIVINGSTONE, AM;FATHMAN, CG;INABA, K;STEINMAN, RM
The capacity of dendritic cells to present protein antigens has been studied with two MHC class II-restricted, myoglobin-specific, T cell clones. Spleen dendritic cells and cultured epidermal Langerhans cells (LC) presented native myoglobin weakly and often not at all. These same populations were powerful stimulators of allogeneic T cells in the primary MLR. Freshly isolated LC were in contrast very active in presenting proteins to T cell clones but were weak stimulators of the MLR. Both fresh and cultured LC could present specific peptide fragments of myoglobin to the clones. These results suggest that dendritic cells in nonlymphoid tissues like skin can act as sentinels for presenting antigens in situ, their accessory function developing in two phases. First antigens are captured and appropriately presented. Further handling of antigen then is downregulated while the cells acquire strong sensitizing activity for the growth and function of resting T lymphocytes. The potent MLR stimulating activity of cultured epidermal LC and lymphoid dendritic cells probably reflects prior handling of antigens leading to the formation of allogeneic MHC-peptide complexes.
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DOI：
10.1084/jem.157.4.1101
发表时间：
1983-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Austyn JM;Steinman RM;Weinstein DE;Granelli-Piperno A;Palladino MA
通讯作者：
Palladino MA
DOI：
10.1084/jem.166.6.1654
发表时间：
1987-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Macatonia SE;Knight SC;Edwards AJ;Griffiths S;Fryer P
通讯作者：
Fryer P
DOI：
10.1073/pnas.84.9.2901
发表时间：
1987-05-01
影响因子：
11.1
作者：
HANAU, D;FABRE, M;CAZENAVE, JP
通讯作者：
CAZENAVE, JP
DOI：
10.1073/pnas.75.10.5132
发表时间：
1978-01-01
影响因子：
11.1
作者：
STEINMAN, RM;WITMER, MD
通讯作者：
WITMER, MD
DOI：
10.1084/jem.166.2.583
发表时间：
1987-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Morel PA;Livingstone AM;Fathman CG
通讯作者：
Fathman CG