Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders.
Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders.
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DOI：
10.1016/j.biopsych.2011.01.041
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发表时间：
2011-07-01
影响因子：
10.6
通讯作者：
Wykes, Til
中科院分区：
文献类型：
--
作者：
Carter, Cameron S.;Barch, Deanna M.;Bullmore, Edward T.;Breiling, James;Buchanan, Robert W.;Butler, Pamela;Cohen, Jonathan D.;Geyer, Mark;Gollub, Randy;Green, Michael F.;Jaeger, Judith;Krystal, John H.;Moore, Holly;Nuechterlein, Keith;Robbins, Trevor;Silverstein, Steven;Smith, Edward E.;Strauss, Milton;Wykes, Til
CNTRICS（认知神经科学治疗研究，以改善认知精神分裂症）倡议，由NIMH的R13资助，旨在通过将认知神经科学的工具开发为对行为和脑功能治疗效果的有用措施，加强精神分裂症认知受损治疗开发的转化研究。最初的一系列会议侧重于从认知神经科学中选择一组新的任务，用于测量对特定认知和神经系统的治疗效果。随后的验证和优化研究正在进行中，一个具有良好心理测量特性的验证措施子集将于2011年普遍可用。本文描述了CNTRICS第二阶段第一次会议的结果，该会议旨在开发成像生物标志物和改进的动物模型，以加强转化研究。在这次会议上，我们考虑了与使用方法相关的问题，如fMRI，EEG，EMG和经颅磁模拟（TMS）作为治疗开发的生物标志物。我们探索了每种方法测量的信号的生物学性质，其有效性和可靠性作为认知相关神经活动的测量，与药物对感兴趣信号的影响相关的潜在混淆，以及与其在临床前使用相关的概念，方法和实用问题，首先进入人体和多中心II期和III期研究。这篇综述论文描述了会议的背景和目标，以及在本卷《生物精神病学》中出现的随附论文中更详细讨论的主要问题的摘要。
The CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) initiative, funded by an R13 from the NIMH, seeks to enhance translational research in treatment development for impaired cognition in schizophrenia by developing tools from cognitive neuroscience into useful measures of treatment effects on behavior and brain function. An initial series of meetings focused on the selection of a new set of tasks from cognitive neuroscience for the measurement of treatment effects on specific cognitive and neural systems. Subsequent validation and optimization studies are underway and a subset of validated measures with well characterized psychometric properties will be generally available in 2011. This article describes results of the first meeting of the second phase of CNTRICS, which seeks to develop imaging biomarkers and improved animal models to enhance translational research. In this meeting we considered issues related to the use of methods such as fMRI, EEG, EMG, and transcranial magnetic simulation (TMS) as Biomarkers for treatment development. We explored the biological nature of the signals measured by each method, their validity and reliability as measures of cognition related neural activity, potential confounds related to drug effects on the signal of interest, and conceptual, methodological and pragmatic issues related to their use in preclinical, first into human and multicenter phase II and III studies. This overview paper describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying papers appearing in this volume of Biological Psychiatry.
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影响因子：
10.6
作者：
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