Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia.
Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia.
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DOI：
10.1016/j.biopsych.2011.02.031
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发表时间：
2011-07-01
影响因子：
10.6
通讯作者：
Pascual-Leone, Alvaro
中科院分区：
文献类型：
--
作者：
McClintock, Shawn M.;Freitas, Catarina;Oberman, Lindsay;Lisanby, Sarah H.;Pascual-Leone, Alvaro
关键词：
经颅磁刺激 (TMS) 是一种神经精神病学工具，可以作为更好地了解认知功能、行为和情绪处理的神经生物学的有用方法。本文的目的是检验 TMS 作为测量一般神经精神疾病（特别是精神分裂症）新皮质功能的手段的实用性，用于改善精神分裂症认知的认知神经科学治疗研究 (CNTRICS) 计划。当将 TMS 范式纳入研究中时，方法学考虑因素包括 TMS 的技术方面、队列选择和混杂因素以及受试者安全性。现有证据表明，单独使用 TMS 或与神经生理学和神经影像学方法结合使用，包括正电子发射断层扫描 (PET)、单光子发射计算机断层扫描 (SPECT)、磁共振成像 (MRI)、功能性 MRI (fMRI)、功能性近红外光谱 (fNIRS)、脑磁图 (MEG) 和脑电图 (EEG)，可探索新皮质功能。通过多种TMS技术，包括单脉冲、成对脉冲、成对联想刺激、重复TMS和θ突发刺激，结合神经生理学和神经影像学方法，存在大量的TMS实验范式来调节不同的新皮质生理过程。具体来说，TMS 可以测量皮质兴奋性、皮质内抑制和兴奋机制以及局部和网络皮质可塑性。与功能和电生理学模式相结合，TMS 可以深入了解健康神经发育和衰老以及神经精神病理学的潜在机制。因此，TMS 可能是 CNTRICS 生物标志物方法装备库中的有用工具。未来的研究有必要为此目的优化 TMS 方法。
Transcranial magnetic stimulation (TMS) is a neuropsychiatric tool that can serve as a useful method to better understand the neurobiology of cognitive function, behavior, and emotional processing. The purpose of this paper is to examine the utility of TMS as a means of measuring neocortical function in neuropsychiatric disorders in general, and schizophrenia in particular, for the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. When incorporating TMS paradigms in research studies, methodological considerations include technical aspects of TMS, cohort selection and confounding factors, and subject safety. Available evidence suggests benefits of TMS alone or in combination with neurophysiologic and neuroimaging methods, including positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), functional MRI (fMRI), functional near infrared spectroscopy (fNIRS), magnetoencephalography (MEG), and electroencephalography (EEG), to explore neocortical function. With the multiple TMS techniques including single-pulse, paired-pulse, paired associative stimulation, and repetitive TMS and theta burst stimulation, combined with neurophysiologic and neuroimaging methods, there exists a plethora of TMS experimental paradigms to modulate different neocortical physiologic processes. Specifically, TMS can measure cortical excitability, intracortical inhibitory and excitatory mechanisms, and local and network cortical plasticity. Coupled with functional and electrophysiological modalities, TMS can provide insight into the mechanisms underlying healthy neurodevelopment and aging, as well as neuropsychiatric pathology. Thus, TMS could be a useful tool in the CNTRICS armamentarium of biomarker methods. Future investigations are warranted to optimize TMS methodologies for this purpose.
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影响因子：
1.1
作者：
Chen, Robert;Udupa, Kaviraja
通讯作者：
Udupa, Kaviraja
影响因子：
7.6
作者：
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通讯作者：
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DOI：
10.1016/j.clinph.2010.05.019
发表时间：
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期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
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通讯作者：
Pascual-Leone A
影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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