Cancers Related to Immunodeficiencies: Update and Perspectives.
Cancers Related to Immunodeficiencies: Update and Perspectives.
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DOI：
10.3389/fimmu.2016.00365
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发表时间：
2016
影响因子：
7.3
通讯作者：
Adcock IM
中科院分区：
文献类型：
--
作者：
Mortaz E;Tabarsi P;Mansouri D;Khosravi A;Garssen J;Velayati A;Adcock IM
由于最近治疗策略的改进，原发性和继发性免疫缺陷患者的寿命正在延长。虽然原发性免疫缺陷 (PID) 的发病率为 1:10,000 新生儿，但继发性免疫缺陷更为常见，并且与移植后免疫功能障碍、人类免疫缺陷病毒的免疫抑制药物或人类 T 细胞嗜淋巴细胞病毒感染有关。感染后，恶性肿瘤是儿童和成人（PID）最常见的死亡原因。与癌症更常见的 PID 包括常见变异型免疫缺陷 (CVID)、Wiskott-Aldrich 综合征、共济失调毛细血管扩张症和严重联合免疫缺陷。这表明存在针对传染性非自身（病原体）和恶性自我挑战（癌症）的保护性免疫反应。癌症发病率的增加归因于改变或“转化”细胞的消除缺陷和/或对癌细胞的免疫缺陷。 PID 中发生的异常免疫监视的概念得到了小鼠和移植后接受免疫抑制的患者的证据的支持。在这里，我们讨论了 PID 缺陷在恶性肿瘤发展中的重要性以及当前与这些疾病的分子发病机制相关的局限性，并强调需要进一步了解特定突变如何调节免疫系统以改变免疫监视，从而在 PID 患者恶性肿瘤的病因学中发挥关键作用。
The life span of patients with primary and secondary immunodeficiency is increasing due to recent improvements in therapeutic strategies. While the incidence of primary immunodeficiencies (PIDs) is 1:10,000 births, that of secondary immunodeficiencies are more common and are associated with posttransplantation immune dysfunction, with immunosuppressive medication for human immunodeficiency virus or with human T-cell lymphotropic virus infection. After infection, malignancy is the most prevalent cause of death in both children and adults with (PIDs). PIDs more often associated with cancer include common variable immunodeficiency (CVID), Wiskott–Aldrich syndrome, ataxia-telangiectasia, and severe combined immunodeficiency. This suggests that a protective immune response against both infectious non-self-(pathogens) and malignant self-challenges (cancer) exists. The increased incidence of cancer has been attributed to defective elimination of altered or “transformed” cells and/or defective immunity towards cancer cells. The concept of aberrant immune surveillance occurring in PIDs is supported by evidence in mice and from patients undergoing immunosuppression after transplantation. Here, we discuss the importance of PID defects in the development of malignancies and the current limitations associated with molecular pathogenesis of these diseases and emphasize the need for further knowledge of how specific mutations can modulate the immune system to alter immunosurveillance and thereby play a key role in the etiology of malignancies in PID patients.
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影响因子：
7.3
作者：
Al-Herz W;Bousfiha A;Casanova JL;Chatila T;Conley ME;Cunningham-Rundles C;Etzioni A;Franco JL;Gaspar HB;Holland SM;Klein C;Nonoyama S;Ochs HD;Oksenhendler E;Picard C;Puck JM;Sullivan K;Tang ML
通讯作者：
Tang ML
影响因子：
14.9
作者：
Bresnick EH;Katsumura KR;Lee HY;Johnson KD;Perkins AS
通讯作者：
Perkins AS
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
13.6
作者：
Brandt, Daniel;Gershwin, M. Eric
通讯作者：
Gershwin, M. Eric
影响因子：
2.6
作者：
Aghamohammadi, A;Parvaneh, N;Webster, D
通讯作者：
Webster, D