Adolescent Intermittent Ethanol (AIE) Enhances the Dopaminergic Response to Ethanol within the Mesolimbic Pathway during Adulthood: Alterations in Cholinergic/Dopaminergic Genes Expression in the Nucleus Accumbens Shell.
Adolescent Intermittent Ethanol (AIE) Enhances the Dopaminergic Response to Ethanol within the Mesolimbic Pathway during Adulthood: Alterations in Cholinergic/Dopaminergic Genes Expression in the Nucleus Accumbens Shell.
复制标题
DOI：
10.3390/ijms222111733
复制
发表时间：
2021-10-29
影响因子：
5.6
通讯作者：
Rodd ZA
中科院分区：
文献类型：
--
作者：
Hauser SR;Mulholland PJ;Truitt WA;Waeiss RA;Engleman EA;Bell RL;Rodd ZA
A consistent preclinical finding is that exposure to alcohol during adolescence produces a persistent hyperdopaminergic state during adulthood. The current experiments determine that effects of Adolescent Intermittent Ethanol (AIE) on the adult neurochemical response to EtOH administered directly into the mesolimbic dopamine system, alterations in dendritic spine and gene expression within the nucleus accumbens shell (AcbSh), and if treatment with the HDACII inhibitor TSA could normalize the consequences of AIE. Rats were exposed to the AIE (4 g/kg ig; 3 days a week) or water (CON) during adolescence, and all testing occurred during adulthood. CON and AIE rats were microinjected with EtOH directly into the posterior VTA and dopamine and glutamate levels were recorded in the AcbSh. Separate groups of AIE and CON rats were sacrificed during adulthood and Taqman arrays and dendritic spine morphology assessments were performed. The data indicated that exposure to AIE resulted in a significant leftward and upward shift in the dose-response curve for an increase in dopamine in the AcbSh following EtOH microinjection into the posterior VTA. Taqman array indicated that AIE exposure affected the expression of target genes (Chrna7, Impact, Chrna5). The data indicated no alterations in dendritic spine morphology in the AcbSh or any alteration in AIE effects by TSA administration. Binge-like EtOH exposure during adolescence enhances the response to acute ethanol challenge in adulthood, demonstrating that AIE produces a hyperdopaminergic mesolimbic system in both male and female Wistar rats. The neuroadaptations induced by AIE in the AcbSh could be part of the biological basis of the observed negative consequences of adolescent binge-like alcohol exposure on adult drug self-administration behaviors.
登录
查看更多内容
影响因子：
4.7
作者：
Abreu-Villaca, Yael;de Carvalho Graca, Anna Caroline;Filgueiras, Claudio C.
通讯作者：
Filgueiras, Claudio C.
DOI：
10.1111/j.1530-0277.2009.00985.x
发表时间：
2009-09-01
影响因子：
3.2
作者：
Ding, Zheng-Ming;Rodd, Zachary A.;McBride, William J.
通讯作者：
McBride, William J.
DOI：
10.1111/j.1530-0277.2008.00806.x
发表时间：
2008-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
通讯作者：
Grant BF
影响因子：
4.2
作者：
Hansen, Henrik H.;Timmermann, Daniel B.;Mikkelsen, Jens D.
通讯作者：
Mikkelsen, Jens D.
DOI：
10.1016/j.alcohol.2011.02.304
发表时间：
2011-09
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Engleman EA;Keen EJ;Tilford SS;Thielen RJ;Morzorati SL
通讯作者：
Morzorati SL