Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy.
Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy.
复制标题
DOI：
10.1039/d1tb02693c
复制
发表时间：
2022-02-09
影响因子：
7
通讯作者：
Wu, Xuanjun
中科院分区：
文献类型：
--
作者：
Dong, Huiling;Gao, Yanan;Huang, Xuefei;Wu, Xuanjun
癌症是一个多方面的全球健康问题，需要持续采取行动开发下一代癌症治疗诊断学。受吲哚菁绿色（ICG）（唯一临床批准的用于癌症光疗的近红外（NIR）染料）的新兴用途的启发，在此我们通过将ICG分别通过Sia的C2和C9位置偶联到唾液酸（Sia）来合成两种ICG缀合物治疗诊断剂，称为Sia-C2-ICG和Sia-C9-ICG。令人鼓舞的是，Sia-C2/C9-ICG显示出上级的体外性质，包括增强的稳定性、降低的与血清蛋白的非特异性结合和改善的血液相容性，突出了Sia偶联的益处。值得注意的是，体内NIR成像显示Sia-C9-ICG显著促进肿瘤靶向并有效缩短体内循环时间，而Sia-C2-ICG在靶向肿瘤方面上级ICG但劣于Sia-C9-ICG。此外，Sia-C9-ICG与NIR激光照射的组合可以导致对癌细胞的优异的光热和光动力疗法，从而导致上级实体肿瘤消融。据我们所知，这是Sia-NIR缀合物在体内实现显著肿瘤减少的第一个报道。总之，这些进展使Sia-C9-ICG成为下一代癌症治疗诊断学的有吸引力的领导者，可以在临床上转化为治疗人类患者。
Cancer is a multifaceted global health problem that requires continuous action to develop next-generation cancer theranostics. Inspired by the emerging use of indocyanine green (ICG), the only clinically approved near-infrared (NIR) dye for cancer phototherapy, here we synthesized two ICG conjugate theranostics by coupling ICG to sialic acid (Sia) through the C2 and C9 positions of Sia, respectively, referred to as Sia-C2–ICG and Sia-C9–ICG. Encouragingly, Sia-C2/C9–ICGs show superior in vitro properties, including enhanced stability, reduced non-specific binding to serum proteins, and improved blood compatibility, highlighting the benefits of Sia coupling. Notably, in vivo NIR imaging shows that Sia-C9–ICG significantly promotes tumor targeting and effectively prolongs the circulation time in the body, while Sia-C2–ICG is superior to ICG but inferior to Sia-C9–ICG in targeting tumors. Furthermore, Sia-C9–ICG combined with NIR laser irradiation can lead to excellent photothermal and photodynamic therapies for cancer cells, resulting in superior solid tumor ablation. To our knowledge, this is the first report of Sia–NIR conjugates achieving significant tumor reduction in vivo. Together, these advances render Sia-C9–ICG an attractive lead as next-generation cancer theranostics that can be translated clinically to treat human patients.
登录
查看更多内容
影响因子：
14
作者：
Gao Y;Zhao Q;Xiao M;Huang X;Wu X
通讯作者：
Wu X
影响因子：
2.5
作者：
Gotoh, Kunihito;Yamada, Terumasa;Imaoka, Shingi
通讯作者：
Imaoka, Shingi
临床试验装置研究中金纳米壳局部光热消融前列腺肿瘤
DOI：
10.1073/pnas.1906929116
发表时间：
2019-09-10
影响因子：
11.1
作者：
Rastinehad, Ardeshir R.;Anastos, Harry;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
影响因子：
19
作者：
Lee, Chia-Hung;Cheng, Shih-Hsun;Lo, Leu-Wei
通讯作者：
Lo, Leu-Wei
DOI：
10.3390/ma6030817
发表时间：
2013-03-06
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Ormond AB;Freeman HS
通讯作者：
Freeman HS