Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis.
Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis.
复制标题
尿苷二磷酸-葡萄糖醛酸基转移酶 2B15 D85Y 基因多态性与较低的前列腺癌风险相关：系统评价和荟萃分析
DOI：
10.18632/oncotarget.17375
复制
发表时间：
2017-08-08
期刊：
影响因子：
--
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Zhong X;Feng J;Xiao Y;Wang P;Fan Q;Wu R;Hu W;Huang C
UGT2B15（尿苷二磷酸 - 葡糖醛酸基转移酶2B15）催化亲脂性C19类固醇雄激素（如二氢睾酮（DHT））转化为可排泄的水溶性代谢物。关于UGT2B15基因D85Y多态性与前列腺癌之间关联的研究得出了相互矛盾的结果。因此，我们在PubMed、EMBASE、Science Direct/Elsevier、中国知网（CNKI）和Cochrane图书馆数据库中进行了系统检索，并确定了六项相关研究，以便对UGT2B15 D85Y多态性与前列腺癌风险之间的关系进行荟萃分析。我们的荟萃分析显示，在所有遗传模型中，UGT2B15 D85Y基因多态性与前列腺癌之间存在显著关联（P<0.05）。合并优势比和95%置信区间如下：相加模型为0.53（0.32 - 0.88）；显性模型为0.51（0.33 - 0.79）；隐性模型为0.76（0.60 - 0.96）；共显性模型为0.55（0.35 - 0.86）；等位基因模型为0.70（0.55 - 0.89）。这些结果与UGT2B15 D85Y酶变体通过有效代谢与前列腺癌进展相关的二氢睾酮（DHT）从而降低前列腺癌风险的观点一致。
UGT2B15 (uridine diphosphate-glucuronosyltransferase 2B15) catalyzes the conversion of lipophilic C19 steroid androgens such as dihydrotestosterone (DHT) into water-soluble metabolites that can be excreted. Studies of the association between the UGT2B15 gene D85Y polymorphism and prostate cancer have yielded contradictory results. We therefore systematically searched in the PubMed, EMBASE, Science Direct/Elsevier, CNKI, and Cochrane Library databases, and identified six relevant studies with which to perform a meta-analysis of the relation between UGT2B15 D85Y polymorphism and prostate cancer risk. Our meta-analysis revealed a significant association between UGT2B15 D85Y gene polymorphism and prostate cancer in all genetic models (P<0.05). The combined odds ratios and 95% confidence intervals were as follows: additive model, 0.53 and 0.32-0.88; dominant model, 0.51 and 0.33-0.79; recessive model, 0.76 and 0.60-0.96; co-dominant model, 0.55 and 0.35-0.86; and allele model, 0.70 and 0.55-0.89. These results are consistent with the idea that the UGT2B15 D85Y enzyme variant reduces the risk of prostate cancer by efficiently metabolizing dihydrotestosterone (DHT), which is associated with prostate cancer progression.
登录
查看更多内容
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
1.4
作者：
Grant, Delores J.;Hoyo, Cathrine;Freedland, Stephen J.
通讯作者：
Freedland, Stephen J.
影响因子：
30.8
作者：
Eeles, Rosalind A.;Al Olama, Ali Amin;Benlloch, Sara;Saunders, Edward J.;Leongamornlert, Daniel A.;Tymrakiewicz, Malgorzata;Ghoussaini, Maya;Luccarini, Craig;Dennis, Joe;Jugurnauth-Little, Sarah;Dadaev, Tokhir;Neal, David E.;Hamdy, Freddie C.;Donovan, Jenny L.;Muir, Ken;Giles, Graham G.;Severi, Gianluca;Wiklund, Fredrik;Gronberg, Henrik;Haiman, Christopher A.;Schumacher, Fredrick;Henderson, Brian E.;Le Marchand, Loic;Lindstrom, Sara;Kraft, Peter;Hunter, David J.;Gapstur, Susan;Chanock, Stephen J.;Berndt, Sonja I.;Albanes, Demetrius;Andriole, Gerald;Schleutker, Johanna;Weischer, Maren;Canzian, Federico;Riboli, Elio;Key, Tim J.;Travis, Ruth C.;Campa, Daniele;Ingles, Sue A.;John, Esther M.;Hayes, Richard B.;Pharoah, Paul D. P.;Pashayan, Nora;Khaw, Kay-Tee;Stanford, Janet L.;Ostrander, Elaine A.;Signorello, Lisa B.;Thibodeau, Stephen N.;Schaid, Dan;Maier, Christiane;Vogel, Walther;Kibel, Adam S.;Cybulski, Cezary;Lubhiski, Jan;Cannon-Albright, Lisa;Brenner, Hermann;Park, Jong Y.;Kaneva, Radka;Batra, Jyotsna;Spurdle, Amanda B.;Clements, Judith A.;Teixeira, Manuel R.;Dicks, Ed;Lee, Andrew;Dunning, Alison M.;Baynes, Caroline;Conroy, Don;Maranian, Melanie J.;Ahmed, Shahana;Govindasami, Koveela;Guy, Michelle;Wilkinson, Rosemary A.;Sawyer, Emma J.;Morgan, Angela;Dearnaley, David P.;Horwich, Alan;Huddart, Robert A.;Khoo, Vincent S.;Parker, Christopher C.;Van As, Nicholas J.;Woodhouse, Christopher J.;Thompson, Alan;Dudderidge, Tim;Ogden, Chris;Cooper, Colin S.;Lophatananon, Artitaya;Cox, Angela;Southey, Melissa C.;Hopper, John L.;English, Dallas R.;Aly, Markus;Adolfsson, Jan;Xu, Jiangfeng;Zheng, Siqun L.;Yeager, Meredith;Kaaks, Rudolf;Diver, W. Ryan;Gaudet, Mia M.;Stern, Mariana C.;Corral, Roman;Joshi, Amit D.;Shahabi, Ahva;Wahlfors, Tiina;Tammela, Teuvo L. J.;Auvinen, Anssi;Virtamo, Jarmo;Klarskov, Peter;Nordestgaard, Borge G.;Roder, M. Andreas;Nielsen, Sune F.;Bojesen, Stig E.;Siddiq, Afshan;FitzGerald, Liesel M.;Kolb, Suzanne;Kwon, Erika M.;Karyadi, Danielle M.;Blot, William J.;Zheng, Wei;Cai, Qiuyin;McDonnell, Shannon K.;Rinckleb, Antje E.;Drake, Bettina;Colditz, Graham;Wokolorczyk, Dominika;Stephenson, Robert A.;Teerlink, Craig;Muller, Heiko;Rothenbacher, Dietrich;Sellers, Thomas A.;Lin, Hui-Yi;Slavov, Chavdar;Mitev, Vanio;Lose, Felicity;Srinivasan, Srilakshmi;Maia, Sofia;Paulo, Paula;Lange, Ethan;Cooney, Kathleen A.;Antoniou, Antonis C.;Vincent, Daniel;Bacot, Francois;Tessier, Daniel C.;Kote-Jarai, Zsofia;Easton, Douglas F.
通讯作者：
Easton, Douglas F.
影响因子：
3.4
作者：
He, Xi;Hesse, Leah M.;Court, Michael H.
通讯作者：
Court, Michael H.
影响因子：
2.9
作者：
Lévesque, É;Turgeon, D;Bélanger, A
通讯作者：
Bélanger, A