Early Development of the Central and Peripheral Nervous Systems Is Coordinated by Wnt and BMP Signals
Early Development of the Central and Peripheral Nervous Systems Is Coordinated by Wnt and BMP Signals
复制标题
中枢和周围神经系统的早期发育是由 Wnt 和 BMP 信号协调的
作者：
Cedric Patthey;Lena Gunhaga;T. Edlund
处理感觉信息的功能神经回路的形成需要中枢神经系统和外周神经系统的协调发展，这些神经系统分别来自神经板和神经板边缘细胞。神经板、神经脊和吻侧胎盘细胞都是原肠胚晚期的特异体。然而，中枢神经系统和外周神经系统的早期发育是如何协调的，仍然知之甚少。以往的研究结果表明，在原肠发育后期，Wnt的渐变信号对神经板细胞施加了吻尾特征，而骨形态发生蛋白(BMP)信号指定了前脑吻端水平的嗅觉细胞和晶状体胎盘细胞。通过对神经峰和胎盘细胞分化的体外分析，我们现在提供了Wnt信号在原肠胚晚期对神经板边缘细胞施加尾部特征的证据，并且在这些条件下，BMP信号诱导神经峰而不是吻端胎盘细胞。我们还提供了证据表明，尾神经和尾神经板缘细胞在头部折叠阶段变得不受进一步暴露于Wnt信号的影响。因此，原肠胚晚期外胚层细胞中Wnt信号的状态调节神经板和神经板缘的肩尾模式，为中枢和周围神经系统的早期发育提供协调的空间和时间控制。
The formation of functional neural circuits that process sensory information requires coordinated development of the central and peripheral nervous systems derived from neural plate and neural plate border cells, respectively. Neural plate, neural crest and rostral placodal cells are all specified at the late gastrula stage. How the early development of the central and peripheral nervous systems are coordinated remains, however, poorly understood. Previous results have provided evidence that at the late gastrula stage, graded Wnt signals impose rostrocaudal character on neural plate cells, and Bone Morphogenetic Protein (BMP) signals specify olfactory and lens placodal cells at rostral forebrain levels. By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions, BMP signals induce neural crest instead of rostral placodal cells. We also provide evidence that both caudal neural and caudal neural plate border cells become independent of further exposure to Wnt signals at the head fold stage. Thus, the status of Wnt signaling in ectodermal cells at the late gastrula stage regulates the rostrocaudal patterning of both neural plate and neural plate border, providing a coordinated spatial and temporal control of the early development of the central and peripheral nervous systems.
影响因子：
11.8
作者：
Lekven, AC;Thorpe, CJ;Moon, RT
通讯作者：
Moon, RT
影响因子：
4.6
作者：
Robert Kos;M. Reedy;Randy L. Johnson;C. Erickson
通讯作者：
Robert Kos;M. Reedy;Randy L. Johnson;C. Erickson
影响因子：
2.7
作者：
Chapman, SC;Schubert, FR;Lumsden, A
通讯作者：
Lumsden, A