Clinical and Laboratory Diagnosis of Legionella Pneumonia.
Clinical and Laboratory Diagnosis of Legionella Pneumonia.
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军团菌肺炎的临床和实验室诊断
DOI：
10.3390/diagnostics13020280
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发表时间：
2023-01-12
期刊：
影响因子：
3.6
通讯作者：
Li, Yuanyuan
中科院分区：
文献类型：
--
作者：
Bai, Lu;Yang, Wei;Li, Yuanyuan
军团菌肺炎是一种相对罕见但极其进行性的肺部感染，死亡率很高。传统的培养分离仍然是诊断军团菌肺炎的金标准。然而，其苛刻的培养条件、较长的周转时间和较差的灵敏度不能满足临床对快速准确诊断的需要，特别是对危重患者。到目前为止，病原学检测技术包括血清学检测、尿抗原检测、质谱学检测以及核酸扩增技术，各有其优点和局限性。本文综述了军团菌肺炎的临床特点和影像表现，讨论了各种病原学检测技术在军团菌肺炎诊断中的应用进展、优势和局限性。旨在为临床实践中军团菌肺炎的早期识别和诊断提供快速准确的指导选择，进一步减轻医疗负担。
Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden.
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影响因子：
5.2
作者：
Chauhan D;Shames SR
通讯作者：
Shames SR
DOI：
10.1164/ajrccm.149.3.8118629
发表时间：
1994-03-01
影响因子：
24.7
作者：
CARRATALA, J;GUDIOL, F;MANRESA, F
通讯作者：
MANRESA, F
影响因子：
3.7
作者：
Babady, N. Esther
通讯作者：
Babady, N. Esther
影响因子：
11.8
作者：
Benin, AL;Benson, RF;Besser, RE
通讯作者：
Besser, RE
影响因子：
4.4
作者：
Cunha BA
通讯作者：
Cunha BA