Dysbiosis Disconnect Between Research and Clinical Practice.
Dysbiosis Disconnect Between Research and Clinical Practice.
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研究与临床实践之间的生态失调脱节。
DOI：
10.1089/jwh.2020.8394
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Wright,MichelleLynn
中科院分区：
文献类型：
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作者：
Wright,MichelleLynn
几种情况，如早产和细菌性阴道病，与细菌的存在有关，如阴道加德纳菌和阴道变形菌。然而，这些微生物的存在并不总是与病理学相关。例如，G. vagelis和A.阴道炎存在于有和没有细菌性阴道病症状的妇女中。1-3基因组测序方法的进步导致了多项研究，重点是识别和分类阴道微生物，以帮助解决一些与微生物相关的临床难题。通过宏基因组测序对阴道微生物群的表征在很大程度上支持了长期以来的教条，即低微生物多样性和乳杆菌属物种在育龄妇女中最占主导地位，无论地理位置、种族或民族如何。然而，具有不同类型的乳酸菌和非乳酸菌占主导地位的阴道微生物组的女性比例因年龄，种族，民族和地理位置而异。3，5，6卷曲乳杆菌在非西班牙裔白色女性中最为普遍，而惰性乳杆菌在美国的亚洲、西班牙裔和非洲裔美国女性中更为普遍。此外，* 40%的西班牙裔和非洲裔美国妇女的阴道微生物组由复杂的微生物群落组成，很少或没有乳酸杆菌存在。3，5妇女的微生物群落类型可能是可变的，群落类型之间的转换是常见的。7，8微生物群落的变化可能发生在整个月经周期、性活动和怀孕期间。7-9在这一期的《女性健康杂志》上，威尔斯等人报告了对美国黑人女性阴道微生物组研究的系统综述。在确定的研究中，大多数研究评估了与细菌性阴道病，艾滋病毒感染和早产有关的黑人妇女阴道微生物组的差异。无论研究的临床结果如何，几乎所有的研究都报告了在受影响和未受影响的群体中，有大量的黑人女性患有乳酸杆菌和非乳酸杆菌占主导地位的微生物群。如前所述，L。在所有研究中，iners是黑人女性中最常见的乳杆菌物种。作者还报告了多种微生物
Several conditions, such as preterm birth and bacterial vaginosis, are associated with the presence of bacteria such as Gardnerella vaginalis and Atopobium vaginae. However, the presence of these microbes is not always associated with pathology. For example, G. vaginalis and A. vaginae are present in women with and without symptoms of bacterial vaginosis. 1–3 Advances in genomic sequencing methods have resulted in multiple studies focused on identifying and classifying vaginal microbes to help solve some of these microbe-associated clinical puzzles. Characterization of the vaginal microbiota via metagenomic sequencing has largely supported the long-standing dogma that low microbial diversity and Lactobacillus species are most predominant among women of reproductive age, regardless of geographic location, race, or ethnicity. 4 However, the proportion of women with different types of Lactobacillus and non-Lactobacillus-dominant vaginal microbiomes varies by age, race, ethnicity, and geographic location. 3, 5, 6Lactobacillus crispatus is most prevalent among non-Hispanic white women and Lactobacillus iners is more prevalent among Asian, Hispanic, and African American women in the United States. 5 In addition,* 40% of Hispanic and African American women have diverse vaginal microbiomes comprised of complex microbial communities, with few to no Lactobacillus present. 3, 5 The type of microbial community a women has can be variable and transitions between community types are common. 7, 8 Shifts in microbial communities may occur throughout the menstrual cycle, with sexual activity, and pregnancy. 7–9 In this issue of the Journal of Women’s Health, Wells et al. report a systematic review of studies investigating the vaginal microbiome among US black women. 10 Of the research studies identified, most studies evaluated differences in the vaginal microbiome among black women related to bacterial vaginosis, HIV infection, and preterm birth. Regardless of the clinical outcome being studied, almost all studies reported a significant number of black women with Lactobacillus and non-Lactobacillus-dominant microbiota in affected and unaffected groups. As previously reported, L. iners was the most common Lactobacillus species present among black women across all studies. The authors also report diverse microbial
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影响因子：
--
作者：
Seibold,JR;MedsgerJr,TA;Winkelstein,A;Kelly,RH;Rodnan,GP
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影响因子：
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作者：
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