Epidemiological and molecular characteristics of HIV infection among money boys and general men who have sex with men in Shanghai, China.
Epidemiological and molecular characteristics of HIV infection among money boys and general men who have sex with men in Shanghai, China.
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在中国上海与男人发生性关系的货币男孩和普通男人中艾滋病毒感染的流行病学和分子特征。
DOI：
10.1016/j.meegid.2015.01.022
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发表时间：
2015-04
影响因子：
3.2
通讯作者：
He, Na
中科院分区：
文献类型：
--
作者：
Yan, Huamei;Ding, Yingying;Wong, Frank Y.;Ning, Zhen;Zheng, Tony;Nehl, Eric J.;He, Na
To examine and compare the epidemiological and molecular characteristics of HIV infection between money boys (MBs) and general men who have sex with men (MSM) in Shanghai, China. Using a venue-based sampling strategy, a total of 535 MSM including 226 MBs and 309 general MSM were recruited to participate in a cross-sectional survey including a face-to-face questionnaire interview and HIV testing. Genotyping of HIV-1 pol gene was performed for HIV-positive participants. Compared with general MSM, MBs reported more sexual partners, more alcohol and drug use and more sex after alcohol or drug use. HIV prevalence was 10.7% overall, 14.6% for MBs and 7.8% for general MSM (p=0.011). Two independent multiple logistic regression analyses indicated that HIV infection was positively associated with non-Han ethnicity (Odds Ratio [OR]=4.79, 95% Confidence Interval [CI]: 1.08–21.28) and sex after drug use in the past 6 months (OR=3.59, 95%CI: 1.50–8.61) among MBs, and with sex after drug use in the past 6 months (OR=3.38, 95%CI: 1.10–10.34) among general MSM as well. HIV-1 pol gene was successfully amplified and sequenced for 52 (91.2%) of HIV-positive participants. Of them, 53.8% were genotyped as CRF01_AE, 36.5% as CRF07_BC and 9.6% as subtype B. Two CRF01_AE subtype-infected participants (3.8%), a 50 years old MB and a 24 years old general MSM, harbored viruses with a M46L mutation conferring resistance to protease inhibitors (PI). MSM particularly MBs in Shanghai, China were at high risk of HIV infection, underscoring an urgent need for joint intervention efforts for drug use and sexual behaviors. HIV drug resistance surveillance is also warranted although the relatively low prevalence of HIV drug resistance implies the effectiveness of current antiretroviral treatment regimen.
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影响因子：
2
作者：
Nehl EJ;He N;Lin L;Zheng T;Harnisch JA;Ding Y;Wong FY
通讯作者：
Wong FY
DOI：
10.1128/genomea.00050-12
发表时间：
2013-01
期刊：
Genome announcements
影响因子：
--
作者：
Han X;An M;Zhang W;Cai W;Chen X;Takebe Y;Shang H
通讯作者：
Shang H
影响因子：
168.9
作者：
Mathers, Bradley M.;Degenhardt, Louisa;Mattick, Richard P.
通讯作者：
Mattick, Richard P.
影响因子：
1.5
作者：
Li, Lin;Sun, Guoqing;Li, Jingyun
通讯作者：
Li, Jingyun
影响因子：
3.2
作者：
Li, Lin;Lu, Xinli;Li, Jingyun
通讯作者：
Li, Jingyun