Hair analysis and its concordance with self-report for drug users presenting in emergency department.
Hair analysis and its concordance with self-report for drug users presenting in emergency department.
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DOI：
10.1016/j.drugalcdep.2016.08.007
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发表时间：
2016-10-01
影响因子：
4.2
通讯作者：
Bogenschutz, Michael P.
中科院分区：
文献类型：
--
作者：
Sharma, Gaurav;Oden, Neal;VanVeldhuisen, Paul C.;Bogenschutz, Michael P.
二次分析使用国家药物滥用治疗临床试验网络随机试验(NCT#01207791)的数据，从6家美国学术医院招募了1,285名患有与药物使用相关的中到严重问题的成年ED患者。目的：探讨毛发分析在不常用药物使用障碍试验中的应用及其与时间线回访(TLFB)的一致性。这项研究将TLFB仪器上自我报告的药物使用情况与四种主要药物类别(大麻、可卡因、处方阿片类药物和街头阿片类药物)的毛发分析中的药物使用生物测量进行了比较。头发分析和TLFB在随访3个月、6个月和12个月时进行，每次都涵盖了访问前90天的召回期。头发样本结果与TLFB之间的一致性在大麻和街头阿片类药物方面很高，但在可卡因和处方阿片类药物方面则是低到中等。在头发样本呈阳性的情况下，与参与者报告服用的其他药物相比，研究参与者指出的作为他们主要选择的药物的漏报使用情况总是大大低于他们报告的其他药物，无论选择的药物是大麻、可卡因、街头阿片类药物还是处方阿片类药物。除了可卡因之外，在头发样本为阴性的情况下，所选药物的过度报告药物使用情况总是明显更高。这项研究扩展了有关毛发分析的文献，支持将其用作临床试验的次要结果衡量标准。
Secondary analysis using data from the National Drug Abuse Treatment Clinical Trials Network randomized trial (NCT # 01207791), in which 1,285 adult ED patients endorsing moderate to severe problems related to drug use were recruited from 6 US academic hospitals. To investigate the utility of hair analysis in drug use disorder trials with infrequent visits, and its concordance with Timeline Follow Back (TLFB). This study compared the self-reported drug use on the TLFB instrument with the biological measure of drug use from hair analysis for four major drug classes (Cannabis, Cocaine, Prescribed Opioids and Street Opioids). Both hair analysis and TLFB were conducted at 3, 6 and 12 month follow-up visit and each covered a 90-day recall period prior to the visit. The concordance between the hair sample results and the TLFB was high for cannabis and street opioids, but was low to moderate for cocaine and prescribed opioids. Under-reporting of drug use given the positive hair sample was always significantly lower for the drug the study participant noted as their primary drug of choice compared with other drugs the participant reported taking, irrespective of whether the drug of choice was cannabis, cocaine, street opioids and prescribed opioids. Over-reporting of drug use given the negative hair sample was always significantly higher for the drug of choice, except for cocaine. This study extends the literature on hair analysis supporting its use as a secondary outcome measure in clinical trials.
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影响因子：
4.2
作者：
Gryczynski, Jan;Schwartz, Robert P.;Mitchell, Shannon Gwin;O'Grady, Kevin E.;Ondersma, Steven J.
通讯作者：
Ondersma, Steven J.
DOI：
10.3109/00952990.2011.596971
发表时间：
2011-09
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Bogenschutz MP;Donovan DM;Adinoff B;Crandall C;Forcehimes AA;Lindblad R;Mandler RN;Oden NL;Perl HI;Walker R
通讯作者：
Walker R
影响因子：
39
作者：
Bogenschutz, Michael P.;Donovan, Dennis M.;Mandler, Raul N.;Perl, Harold I.;Forcehimes, Alyssa A.;Crandall, Cameron;Lindblad, Robert;Oden, Neal L.;Sharma, Gaurav;Metsch, Lisa;Lyons, Michael S.;McCormack, Ryan;Konstantopoulos, Wendy Macias;Douaihy, Antoine
通讯作者：
Douaihy, Antoine
影响因子：
4.4
作者：
Ledgerwood, David M.;Goldberger, Bruce A.;Price, Rumi Kato
通讯作者：
Price, Rumi Kato
影响因子：
12.7
作者：
Kline, J;Ng, SKC;Susser, M
通讯作者：
Susser, M