Hair drug testing results and self-reported drug use among primary care patients with moderate-risk illicit drug use.
Hair drug testing results and self-reported drug use among primary care patients with moderate-risk illicit drug use.
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DOI：
10.1016/j.drugalcdep.2014.05.001
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发表时间：
2014-08-01
影响因子：
4.2
通讯作者：
Ondersma, Steven J.
中科院分区：
文献类型：
--
作者：
Gryczynski, Jan;Schwartz, Robert P.;Mitchell, Shannon Gwin;O'Grady, Kevin E.;Ondersma, Steven J.
本研究旨在研究毛发检测作为药物使用的研究措施在个人与中度风险药物使用的基础上，国际验证的酒精，吸烟和物质参与筛选测试（ASSIST）的效用。本研究是一项二次分析，使用的基线数据来自一项药物滥用短暂干预的随机试验，该试验从美国新墨西哥州的两个社区诊所招募了360名中度风险药物使用的成年人。目前的研究比较了ASSIST上自我报告的药物使用情况与使用标准市售5盘测试对头发样本进行实验室分析的结果，该测试具有检测筛选和气相色谱/质谱（GC/MS）确认。自我报告和头发测试都涵盖了3个月的时间。毛发检测和自我报告之间的总体一致性为57.5%（大麻），86.5%（可卡因），85.8%（安非他明）和74.3%（阿片类药物）。所有药物在标准实验室临界值下毛发检测的特异性超过90%，但毛发检测相对于自我报告的敏感性较低，仅识别出52.3%（127/243）的自我披露的大麻使用者，65.2%（30/46）的可卡因使用者，24.2%（8/33）的安非他明使用者和2.9%（2/68）的阿片类药物使用者。在过去3个月内使用大麻或可卡因的参与者中，毛发测试阴性的参与者倾向于报告使用这些药物的频率较低（大麻和可卡因的p<0.001）。毛发检测在中等风险吸毒者的研究中可能是有用的，但低频率使用的潜在识别不足表明，研究人员应考虑采用低检测截止值，并将毛发检测与自我报告结合使用。
This study sought to examine the utility of hair testing as a research measure of drug use among individuals with moderate-risk drug use based on the internationally-validated Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). This study is a secondary analysis using baseline data from a randomized trial of brief intervention for drug misuse, in which 360 adults with moderate-risk drug use were recruited from two community clinics in New Mexico, USA. The current study compared self-reported drug use on the ASSIST with laboratory analysis of hair samples using a standard commercially-available 5-panel test with assay screening and gas chromatography/mass spectrometry (GC/MS) confirmation. Both self-report and hair testing covered a 3 month period. Overall concordance between hair testing and self-report was 57.5% (marijuana), 86.5% (cocaine), 85.8% (amphetamines), and 74.3% (opioids). Specificity of hair testing at standard laboratory cut-offs exceeded 90% for all drugs, but sensitivity of hair testing relative to self-report was low, identifying only 52.3% (127/243) of self-disclosed marijuana users, 65.2% (30/46) of cocaine users, 24.2% (8/33) of amphetamine users, and 2.9% (2/68) of opioid users. Among participants who disclosed using marijuana or cocaine in the past 3 months, participants with a negative hair test tended to report lower-frequency use of those drugs (p< .001 for marijuana and cocaine). Hair testing can be useful in studies with moderate-risk drug users, but the potential for under-identification of low-frequency use suggests that researchers should consider employing low detection cut-offs and using hair testing in conjunction with self-report.
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DOI：
10.1016/j.jpba.2013.08.050
发表时间：
2014-01-25
影响因子：
3.4
作者：
Montesano, Camilla;Johansen, Sys Stybe;Nielsen, Marie Katrine Klose
通讯作者：
Nielsen, Marie Katrine Klose
影响因子：
8
作者：
Delaney-Black V;Chiodo LM;Hannigan JH;Greenwald MK;Janisse J;Patterson G;Huestis MA;Ager J;Sokol RJ
通讯作者：
Sokol RJ
影响因子：
4.4
作者：
Ledgerwood, David M.;Goldberger, Bruce A.;Price, Rumi Kato
通讯作者：
Price, Rumi Kato
影响因子：
3.8
作者：
Newcombe, DAL;Humeniuk, RE;Ali, R
通讯作者：
Ali, R
影响因子：
2.2
作者：
Vignali, Claudia;Stramesi, Cristiana;Groppi, Angelo
通讯作者：
Groppi, Angelo