Synaptotagmin I delays the fast inactivation of Kv1.4 channel through interaction with its N-terminus.
Synaptotagmin I delays the fast inactivation of Kv1.4 channel through interaction with its N-terminus.
复制标题
Synaptotagmin I 通过与其 N 末端相互作用来延迟 Kv1.4 通道的快速失活。
DOI：
10.1186/1756-6606-7-4
复制
发表时间：
2014-01-14
期刊：
影响因子：
3.6
通讯作者：
Liang S
中科院分区：
文献类型：
--
作者：
Xie C;Su H;Guo T;Yan Y;Peng X;Cao R;Wang Y;Chen P;Wang X;Liang S
The voltage-gated potassium channel Kv1.4 is an important A-type potassium channel and modulates the excitability of neurons in central nervous system. Analysis of the interaction between Kv1.4 and its interacting proteins is helpful to elucidate the function and mechanism of the channel. In the present research, synaptotagmin I was for the first time demonstrated to be an interacting protein of Kv1.4 and its interaction with Kv1.4 channel did not require the mediation of other synaptic proteins. Using patch-clamp technique, synaptotagmin I was found to delay the inactivation of Kv1.4 in HEK293T cells in a Ca2+-dependent manner, and this interaction was proven to have specificity. Mutagenesis experiments indicated that synaptotagmin I interacted with the N-terminus of Kv1.4 and thus delayed its N-type fast inactivation. These data suggest that synaptotagmin I is an interacting protein of Kv1.4 channel and, as a negative modulator, may play an important role in regulating neuronal excitability and synaptic efficacy.
登录
查看更多内容
影响因子：
5.3
作者：
Fili, O;Michaelevski, I;Lotan, I
通讯作者：
Lotan, I
影响因子：
16.2
作者：
Adelman, JP;Bond, CT;Maylie, J
通讯作者：
Maylie, J
影响因子：
56.9
作者：
HOSHI, T;ZAGOTTA, WN;ALDRICH, RW
通讯作者：
ALDRICH, RW
不同大脑区域突触后密度的分离和表征：丰富不同类型的突触后密度。
DOI：
10.1083/jcb.86.3.831
发表时间：
1980-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Carlin RK;Grab DJ;Cohen RS;Siekevitz P
通讯作者：
Siekevitz P
影响因子：
16.2
作者：
BAUKROWITZ, T;YELLEN, G
通讯作者：
YELLEN, G