Cerebral gray matter volume deficits after weight recovery from anorexia nervosa.
Cerebral gray matter volume deficits after weight recovery from anorexia nervosa.
复制标题
神经性厌食症体重恢复后大脑灰质体积不足。
DOI：
10.1001/archpsyc.1997.01830180055006
复制
发表时间：
1997
影响因子：
--
通讯作者：
R. Zipursky
中科院分区：
文献类型：
--
作者：
Evelyn K. Lambe;D. Katzman;David J. Mikulis;Sidney H. Kennedy;R. Zipursky
背景
在患有神经性厌食症（AN）的低体重患者的大脑中观察到结构变化，包括脑脊液（CSF）体积增加以及灰质和白色物质体积减少。我们假设，与对照组相比，从AN中恢复体重的受试者将显示CSF体积升高和灰质体积减少。
方法
我们使用磁共振成像比较了12名体重恢复的AN受试者（体重恢复后的时间，1-23年）与18名健康对照受试者和13名低体重AN患者的大脑。全脑的轴向双回波扫描通过计算机体积方法被分割成灰质、白色物质和CSF隔室。基于对30名健康女性对照组的回归分析，对颅内体积和年龄的显著影响进行了脑测量校正。
结果
测试表明，体重恢复组的CSF体积明显大于对照组，灰质体积明显小于对照组。与低体重患者相比，体重恢复受试者的CSF体积显著较小，灰质和白色物质体积显著较大。在体重恢复组中，CSF升高和灰质缺陷均与体重恢复后的时间长度无关。
结论
从AN体重恢复的受试者中持续的灰质体积缺陷表明，与疾病相关的大脑变化可能存在不可逆的成分。这种不可逆成分的神经病理学特征尚未被表征。
BACKGROUND
Structural changes have been observed in the brains of low-weight patients with anorexia nervosa (AN), including increased cerebrospinal fluid (CSF) volumes and decreased gray matter and white matter volumes. We hypothesized that subjects who are weight-recovered from AN would show elevated CSF volumes and reduced gray matter volumes compared with controls.
METHODS
We used magnetic resonance imaging to compare the brains of 12 subjects who are weight-recovered from AN (time since weight recovery, 1-23 years) with those of 18 healthy control subjects and 13 low-weight patients with AN. Axial, dual-echo scans of the whole brain were segmented into gray matter, white matter, and CSF compartments by means of a computerized volumetric approach. Brain measures were corrected for the significant effects of intracranial volume and age, based on regression analysis of a larger group of 30 healthy female controls.
RESULTS
Tests showed that the weight-recovered group had significantly greater CSF volumes and smaller gray matter volumes than the control group. By comparison with low-weight patients, the weight-recovered subjects had significantly smaller CSF volumes and significantly larger gray matter and white matter volumes. In the weight-recovered group, neither the CSF elevations nor gray matter deficits were correlated with the length of time since weight recovery.
CONCLUSIONS
The persistent gray matter volume deficits in subjects who are weight-recovered from AN suggest that there may be an irreversible component to the brain changes associated with the illness. The neuropathological features of this irreversible component have yet to be characterized.
神经性厌食症患者 CAT 扫描中的心室扩张。
DOI：
10.1176/ajp.143.1.96
发表时间：
1986
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Datlof,S;Coleman,PD;Forbes,GB;Kreipe,RE
通讯作者：
Kreipe,RE
影响因子：
--
作者：
R. Zipursky;K. O. Lim;E. Sullivan;Byron W. Brown;A. Pfefferbaum
通讯作者：
R. Zipursky;K. O. Lim;E. Sullivan;Byron W. Brown;A. Pfefferbaum
影响因子：
--
作者：
PFEFFERBAUM, A;MATHALON, DH;LIM, KO
通讯作者：
LIM, KO