Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: (I) effect of polymer hydrophobicity on its ability to protect liposomes from peroxidation.
Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: (I) effect of polymer hydrophobicity on its ability to protect liposomes from peroxidation.
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PEO-PPO-PEO三嵌段共聚物和脂质膜之间相互作用的性质：（i）聚合物疏水性对保护脂质体免受过氧化氧化的能力的影响。
DOI：
10.1021/bm300847x
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发表时间：
2012-09-10
影响因子：
6.2
通讯作者：
Lee, Ka Yee C.
中科院分区：
文献类型：
--
作者：
Wang, Jia-Yu;Marks, Jeremy;Lee, Ka Yee C.
PEO-PPO-PEO三嵌段共聚物对脂质膜完整性具有相反的作用-它们可以作为膜密封剂或膜透化剂。为了深入了解它们的生物膜活性，研究了一系列基于PEO的聚合物与磷脂囊泡之间的基本相互作用。具体而言，共聚物的疏水性对其防止脂质体过氧化的能力的影响进行了评估，并推导出参与相互作用的分配自由能和系数。我们的研究结果表明，高度的亲水性是共聚物的一个关键特征，可以有效地保护脂质体免受过氧化作用，共聚物的保护作用源于它们在膜表面的吸附，而不渗透到双层核心。聚合物吸收引起的这种保护作用的起源归因于膜水合动力学的延迟，这在动态核极化（DNP）衍生的水合动力学的伴随研究中进一步说明。
PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity- they can behave either as membrane sealants or as membrane permeabilizers. To gain insights into their biomembrane activities, the fundamental interactions between a series of PEO-based polymers and phospholipid vesicles were investigated. Specifically, the effect of copolymer hydrophobicity on its ability to prevent liposomes from peroxidation was evaluated, and partitioning free energy and coefficient involved in the interactions were derived. Our results show that the high degree of hydrophilicity is a key feature of the copolymers that can effectively protect liposomes from peroxidation and the protective effect of the copolymers stems from their adsorption at the membrane surface without penetrating into the bilayer core. The origin of this protective effect induced by polymer absorption is attributed to the retardation of membrane hydration dynamics, which is further illustrated in the accompany study on dynamic nuclear polarization (DNP)-derived hydration dynamics.
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影响因子：
3.4
作者：
Liu, ZQ;Yu, W;Liu, ZL
通讯作者：
Liu, ZL
DOI：
10.1016/s1388-1981(00)00084-6
发表时间：
2000-08-24
影响因子：
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作者：
Borst, JW;Visser, NV;Visser, AJWG
通讯作者：
Visser, AJWG
影响因子：
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作者：
Liégeois, C;Lermusieau, G;Collin, S
通讯作者：
Collin, S
影响因子：
6.1
作者：
Faria, A;Calhau, C;Mateus, N
通讯作者：
Mateus, N
DOI：
10.1073/pnas.89.10.4524
发表时间：
1992-05-15
影响因子：
11.1
作者：
LEE, RC;RIVER, LP;WOLLMANN, RL
通讯作者：
WOLLMANN, RL