Acute pancreatitis associated with severe acute respiratory syndrome coronavirus-2 infection: a case report and review of the literature.
Acute pancreatitis associated with severe acute respiratory syndrome coronavirus-2 infection: a case report and review of the literature.
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DOI：
10.1186/s13256-021-03026-7
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发表时间：
2021-09-09
影响因子：
1
通讯作者：
Elhadi M
中科院分区：
文献类型：
--
作者：
Eldaly AS;Fath AR;Mashaly SM;Elhadi M
我们报告一个以急性胰脏炎为唯一症状的严重急性呼吸系统症候群冠状病毒2型感染病例。据我们所知，很少有相同表现的病例报告。一名来自埃及的健康的44岁白色男性，因严重的上腹痛和十多次非抛射性呕吐（首先是胃内容物，然后是胆汁）而入院。怀疑急性胰腺炎，并通过血清淀粉酶、血清脂肪酶和计算机断层扫描（显示胰腺轻度弥漫性肿大）证实。患者没有任何急性胰腺炎的风险因素，广泛的调查没有发现明确的病因。考虑到潜在的职业暴露，对鼻咽拭子进行了严重急性呼吸综合征冠状病毒2型聚合酶链反应检测，尽管没有严重急性呼吸综合征冠状病毒2型的典型症状，如发热和呼吸道症状，但检测结果为阳性。患者接受保守治疗。对于胰腺炎，他保持2天不口服，并接受静脉内乳酸林格氏液（10 ml/kg/h）、纳布啡、α胰凝乳蛋白酶、奥美拉唑和乳酸赛克力嗪。对于严重急性呼吸综合征冠状病毒2，他接受了5天疗程的静脉注射阿奇霉素（每天500 mg）。他的病情迅速好转，并于第五天出院。我们知道腹痛并不是严重急性呼吸综合征冠状病毒2的罕见症状，我们也知道在严重急性呼吸综合征冠状病毒2患者中报告了血清淀粉酶和脂肪酶水平升高，特别是那些症状严重的患者。然而，严重急性呼吸综合征冠状病毒-2感染和特发性急性胰腺炎之间的关联是罕见的，只有几次报道。我们认为，应进行进一步的研究，以确定严重急性呼吸综合征冠状病毒2型患者胰腺受累的程度和严重急性呼吸综合征冠状病毒2型与急性胰腺炎之间的可能因果关系。我们回顾了严重急性呼吸综合征冠状病毒2型与急性胰腺炎患者之间的相关性的文献。已发表的数据表明，严重急性呼吸综合征冠状病毒2可能是急性胰腺炎的危险因素。
We report a case of Severe acute respiratory syndrome coronavirus-2 infection with acute pancreatitis as the only presenting symptom. To the best of our knowledge, there are few case reports of the same presentation. An otherwise healthy 44-year-old white male from Egypt presented to the hospital with severe epigastric pain and over ten attacks of nonprojectile vomiting (first, gastric content, then bilious). Acute pancreatitis was suspected and confirmed by serum amylase, serum lipase, and computed tomography scan that showed mild diffuse enlargement of the pancreas. The patient did not have any risk factor for acute pancreatitis, and extensive investigations did not reveal a clear etiology. Given a potential occupational exposure, a nasopharyngeal swab for polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 was done, which was positive despite the absence of the typical symptoms of severe acute respiratory syndrome coronavirus 2 such as fever and respiratory symptoms. The patient was managed conservatively. For pancreatitis, he was kept nil per os for 2 days and received intravenous lactated Ringer’s (10 ml per kg per hour), nalbuphine, alpha chymotrypsin, omeprazole, and cyclizine lactate. For severe acute respiratory syndrome coronavirus 2, he received a 5-day course of intravenous azithromycin (500 mg per day). He improved quickly and was discharged by the fifth day. We know that abdominal pain is not a rare symptom of severe acute respiratory syndrome coronavirus 2, and we also know that elevated levels of serum amylase and lipase were reported in severe acute respiratory syndrome coronavirus-2 patients, especially those with severe symptoms. However, the association between severe acute respiratory syndrome coronavirus-2 infection and idiopathic acute pancreatitis is rare and has been reported only a few times. We believe further studies should be conducted to determine the extent of pancreatic involvement in severe acute respiratory syndrome coronavirus-2 patients and the possible causality between severe acute respiratory syndrome coronavirus 2 and acute pancreatitis. We reviewed the literature regarding the association between severe acute respiratory syndrome coronavirus 2 and acute pancreatitis patients. Published data suggest that severe acute respiratory syndrome coronavirus 2 possibly could be a risk factor for acute pancreatitis.
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DOI：
10.14701/ahbps.2020.24.4.539
发表时间：
2020-11-30
期刊：
Annals of hepato-biliary-pancreatic surgery
影响因子：
--
作者：
Kandasamy S
通讯作者：
Kandasamy S
影响因子：
3.6
作者：
Hadi, Amer;Werge, Mikkel;Gluud, Lise Lotte
通讯作者：
Gluud, Lise Lotte
DOI：
10.12890/2020_001710
发表时间：
2020-01-01
影响因子：
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作者：
Meireles, Pedro Antunes;Bessa, Filipe;Alvoeiro, Lourdes
通讯作者：
Alvoeiro, Lourdes
影响因子：
29.4
作者：
Inamdar, Suman;Benias, Petros C.;Trindade, Arvind J.
通讯作者：
Trindade, Arvind J.
影响因子：
20.8
作者：
Mueller, Janis A.;Gross, Ruediger;Kleger, Alexander
通讯作者：
Kleger, Alexander