ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria.
ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria.
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ICEberg：细菌中发现的整合和共轭元素的网络资源
DOI：
10.1093/nar/gkr846
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Ou HY
中科院分区：
文献类型：
--
作者：
Bi D;Xu Z;Harrison EM;Tai C;Wei Y;He X;Jia S;Deng Z;Rajakumar K;Ou HY
ICEberg（http：//db-mml.sjtu.edu.cn/ICEberg/）是一个综合数据库，提供有关细菌中发现的整合和接合元件（ICE）的全面信息。ICE是接合性的自我传递元件，其可以整合到宿主染色体中并从宿主染色体上切除。ICE包含三个典型的模块，整合和切除，接合和调节模块，共同促进垂直遗传和定期横向基因流动。许多ICE携带可能的毒力决定因素、抗生素耐药因子和/或编码其他有益性状的基因。ICEberg提供了一个独特的，高度组织化的，易于探索的预测和实验支持的ICE相关数据档案。目前，它包含了在124种细菌的代表中发现的428种ICE的详细信息，以及超过400个直接相关的参考文献。广泛的相似性搜索，序列比对，基因组背景浏览器，系统发育和其他功能分析工具都可以通过ICEberg轻松访问。我们建议，ICEberg将促进高效，多学科和创新的探索细菌ICE和特别感兴趣的研究人员在原核生物进化，发病机理，生物技术和代谢的广泛领域。将定期维护、更新和改进冰山数据库，以确保其对研究界的持续最大效用。
ICEberg (http://db-mml.sjtu.edu.cn/ICEberg/) is an integrated database that provides comprehensive information about integrative and conjugative elements (ICEs) found in bacteria. ICEs are conjugative self-transmissible elements that can integrate into and excise from a host chromosome. An ICE contains three typical modules, integration and excision, conjugation, and regulation modules, that collectively promote vertical inheritance and periodic lateral gene flow. Many ICEs carry likely virulence determinants, antibiotic-resistant factors and/or genes coding for other beneficial traits. ICEberg offers a unique, highly organized, readily explorable archive of both predicted and experimentally supported ICE-relevant data. It currently contains details of 428 ICEs found in representatives of 124 bacterial species, and a collection of >400 directly related references. A broad range of similarity search, sequence alignment, genome context browser, phylogenetic and other functional analysis tools are readily accessible via ICEberg. We propose that ICEberg will facilitate efficient, multi-disciplinary and innovative exploration of bacterial ICEs and be of particular interest to researchers in the broad fields of prokaryotic evolution, pathogenesis, biotechnology and metabolism. The ICEberg database will be maintained, updated and improved regularly to ensure its ongoing maximum utility to the research community.
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影响因子：
14.9
作者：
Shao Y;Harrison EM;Bi D;Tai C;He X;Ou HY;Rajakumar K;Deng Z
通讯作者：
Deng Z
影响因子：
4.5
作者：
Guglielmini J;Quintais L;Garcillán-Barcia MP;de la Cruz F;Rocha EP
通讯作者：
Rocha EP
影响因子：
4.2
作者：
Ryan MP;Pembroke JT;Adley CC
通讯作者：
Adley CC
影响因子：
4.5
作者：
Wozniak RA;Waldor MK
通讯作者：
Waldor MK
DOI：
10.1007/s10482-008-9255-x
发表时间：
2008-06
影响因子：
2.6
作者：
Poele, Evelien M. te;Bolhuis, Henk;Dijkhuizen, Lubbert
通讯作者：
Dijkhuizen, Lubbert