Total soy saponins improve the antioxidant capacity of the myocardium and exercise ability in exhausted rats.
Total soy saponins improve the antioxidant capacity of the myocardium and exercise ability in exhausted rats.
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DOI：
10.1016/j.jshs.2015.09.005
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发表时间：
2016-12
影响因子：
11.7
通讯作者：
Tang W
中科院分区：
文献类型：
--
作者：
Liu Z;Liu Y;Xiong Z;Feng Y;Tang W
本研究的目的是探讨大豆总皂苷（TS）对运动至力竭大鼠心肌抗氧化能力的影响。使用一次性耗尽的跑步机模型。将所有大鼠分为4组：对照组、TS组、力竭组、TS力竭组。 TS组和TS耗尽组以20mg/kg体重的剂量饲喂TS，每天一次，持续2周。疲惫组接受安慰剂，对照组不接受任何治疗。跑步机速度设定为30米/分钟，大鼠（力竭组和TS力竭组）以此速度训练直至力竭。大鼠筋疲力尽后立即断头并解剖。制备10%的心肌组织匀浆。 TS 显着增加了运动时间 20.62% (p < 0.05)。与对照组相比，TS组过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GR）的酶活性显着增强（p<0.01）； TS 耗尽组中 GR 和 GSH-Px 活性显着增强（p<<0.01）； TS 耗尽组的丙二醛 (MDA) 水平显着降低 (p<0.05)。与力竭组相比，TS力竭组的GSH-Px活性显着增强(p<0.01)； TS 组中 CAT、GSH-Px 和 GR 活性显着增强 (p<<0.01)。与TS组相比，TS耗尽组的CAT和GR活性显着降低（p＜＜0.01）。 TS能不同程度地提高运动大鼠心肌抗氧化活性，降低MDA和血清AST、LDH水平，增加运动时间，延缓运动疲劳的发生。
The aim of the present study was to investigate the impact of total soy saponins (TS) on the myocardial antioxidant capacity in rats exercised to exhaustion. The one-time exhausted treadmill model was used. All rats were divided into 4 groups: the control group, the TS group, the exhausted group, and the TS exhausted group. The TS and TS exhausted groups were fed TS at a dosage of 20 mg/kg body weight, once a day, for 2 weeks. The exhausted group was given a placebo, and the control group was not given any treatment. The treadmill speed was set at 30 m/min, and the rats (exhausted and TS exhausted groups) were trained at this speed until exhausted. The rats were decapitated and anatomized immediately after exhausted. A 10% homogenate of the myocardial tissue was prepared. TS significantly increased the exercise time by 20.62% (p < 0.05). As compared with the control group, the enzyme activities for catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR) were significantly enhanced in the TS group (p < 0.01); GR and GSH-Px activity was significantly enhanced in the TS exhausted group (p < 0.01); malondialdehyde (MDA) levels were significantly decreased in the TS exhausted group (p < 0.05). As compared with the exhausted group, the GSH-Px activity was significantly enhanced in the TS exhausted group (p < 0.01); CAT, GSH-Px, and GR activities were significantly enhanced in the TS group (p < 0.01). As compared with the TS group, the CAT and GR activity in the TS exhausted group was significantly decreased (p < 0.01). TS can improve the exercised rats' antioxidant activity in their cardiac muscle to varying degrees, decrease MDA and serum AST and LDH levels, increase the exercise time, and delay the occurrence of sports fatigue.
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影响因子：
2.7
作者：
Hayashi, K;Hayashi, H;Ikeshiro, Y
通讯作者：
Ikeshiro, Y
影响因子：
4.5
作者：
Neri, Margherita;Fineschi, Vittorio;Cerretani, Daniela
通讯作者：
Cerretani, Daniela
DOI：
10.1249/mss.0b013e318172cf22
发表时间：
2008-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Scharhag, Juergen;George, Keith;Kindermann, Wilfried
通讯作者：
Kindermann, Wilfried
影响因子：
3
作者：
Huang, Chi-Chang;Lin, Tien-Jen;Lin, Wan-Teng
通讯作者：
Lin, Wan-Teng
影响因子：
1
作者：
Asano, Goro;Takashi, En;Sugisaki, Yuhichi
通讯作者：
Sugisaki, Yuhichi