Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases.
Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases.
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DOI：
10.3390/bios11090296
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发表时间：
2021-08-25
期刊：
影响因子：
--
通讯作者：
Inci F
中科院分区：
文献类型：
--
作者：
Erdem Ö;Eş I;Akceoglu GA;Saylan Y;Inci F
慢性病是具有长期症状的非传染性疾病，约占全世界所有死亡人数的70%。对于cd的诊断和预后，准确的生物标志物检测是必不可少的。目前，cd相关生物标志物的检测是通过复杂的平台进行的，在适用性和性能上存在一定的局限性。因此，需要提出适用于即时护理（PoC）环境的创新策略，并提供生物标志物的精确检测。另一方面，特别是在PoC设置中，微针（MN）技术，由微米大小的针排列在微型贴片上，已经成为生物传感策略中的一种革命性方法，为改进现有的PoC设备开辟了新的视野。为了不同的目的，已经制造了各种基于mn的平台，采用了几种技术和材料。近年来，用于实时监测cd相关生物标志物的锰基生物传感器的发展受到了广泛关注。在此，我们总结了MNs的基本概念，包括微加工技术，设计参数，以及它们作为CD诊断生物传感平台的作用机制。此外，本文还介绍了纳米颗粒在CD诊断中的最新进展，并重点介绍了利用纳米颗粒作为生物传感装置进行的相关临床试验。本综述旨在探讨MNs在CD诊断中的潜在应用。
Chronic diseases (CDs) are noncommunicable illnesses with long-term symptoms accounting for ~70% of all deaths worldwide. For the diagnosis and prognosis of CDs, accurate biomarker detection is essential. Currently, the detection of CD-associated biomarkers is employed through complex platforms with certain limitations in their applicability and performance. There is hence unmet need to present innovative strategies that are applicable to the point-of-care (PoC) settings, and also, provide the precise detection of biomarkers. On the other hand, especially at PoC settings, microneedle (MN) technology, which comprises micron-size needles arranged on a miniature patch, has risen as a revolutionary approach in biosensing strategies, opening novel horizons to improve the existing PoC devices. Various MN-based platforms have been manufactured for distinctive purposes employing several techniques and materials. The development of MN-based biosensors for real-time monitoring of CD-associated biomarkers has garnered huge attention in recent years. Herein, we summarize basic concepts of MNs, including microfabrication techniques, design parameters, and their mechanism of action as a biosensing platform for CD diagnosis. Moreover, recent advances in the use of MNs for CD diagnosis are introduced and finally relevant clinical trials carried out using MNs as biosensing devices are highlighted. This review aims to address the potential use of MNs in CD diagnosis.
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