Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia.
Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia.
复制标题
胰腺癌高血糖患者神经改变与神经周围浸润的关系
DOI：
10.1371/journal.pone.0017385
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
Wu E
中科院分区：
文献类型：
--
作者：
Li J;Ma Q;Liu H;Guo K;Li F;Li W;Han L;Wang F;Wu E
背景 与空腹血糖水平较低的患者相比，空腹血糖水平较高的患者胰腺癌死亡率较高。但其原因尚未研究。本研究的目的是检查患有高血糖的胰腺癌患者的神经改变，并确定神经改变与神经周围浸润之间的关系。方法/主要发现 对 61 例福尔马林固定的胰腺癌标本和 10 例正常胰腺（作为对照）的临床和病理特征进行了分析。此外，通过免疫组织化学检查蛋白质基因产物9.5（PGP9.5）、髓磷脂P0蛋白（MPP）、NGF、TrkA和p75的表达。高血糖组的中位神经数量、中位神经组织面积和中位神经直径每10 mm2均大于正常血糖组（分别为p = 0.007、p = 0.009和p = 0.004）。高血糖组 MPP 染色积分光密度（IOD）低于正常血糖组（p = 0.019），而高血糖组 NGF 和 p75 表达水平高于正常血糖组（p = 0.002 和 p = 0.026）。高血糖组胰腺癌的神经束侵犯比正常血糖组更频繁（p = 0.000）。结论/意义高血糖胰腺癌患者的肿瘤微环境中神经损伤和再生同时发生；同时发生可能会加重神经周围侵犯的过程。 NGF和p75的异常表达也可能参与这一过程，从而导致根治性手术率降低。
Background Patients with higher levels of fasting serum glucose have higher death rates from pancreatic cancer compared to patients with lower levels of fasting serum glucose. However, the reasons have not been studied. The goal of the current study was to examine the neural alterations in pancreatic cancer patients with hyperglycemia and to identify the relationship between the neural alterations and perineural invasion. Methodology/Principal Findings The clinical and pathological features of 61 formalin-fixed pancreatic cancer specimens and 10 normal pancreases as controls were analyzed. Furthermore, the expression of Protein Gene Product 9.5 (PGP9.5), Myelin P0 protein (MPP), NGF, TrkA, and p75 were examined by immunohistochemistry. The median number of nerves, the median area of neural tissue, and the median nerve diameter per 10 mm2 were larger in the hyperglycemia group than those in the euglycemia group (p = 0.007, p = 0.009, and p = 0.004, respectively). The integrated optical density (IOD) of MPP staining was lower in the hyperglycemia group than those in the euglycemia group (p = 0.019), while the expression levels of NGF and p75 were higher in the hyperglycemia group than those in the euglycemia group (p = 0.002, and p = 0.026, respectively). The nerve bundle invasion of pancreatic cancer was more frequent in the hyperglycemia group than in the euglycemia group (p = 0.000). Conclusions/Significance Nerve damage and regeneration occur simultaneously in the tumor microenvironment of pancreatic cancer patients with hyperglycemia; the simultaneous occurrence may aggravate the process of perineural invasion. The abnormal expression of NGF and p75 may also be involved in this process and subsequently lead to a lower rate of curative surgery.
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影响因子：
8.2
作者：
Malik, RA;Tesfaye, S;Ward, JD
通讯作者：
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影响因子：
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作者：
Coughlin, SS;Calle, EE;Thun, MJ
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.bpg.2007.10.016
发表时间：
2008-01-01
影响因子：
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作者：
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通讯作者：
Friess, Helmut
影响因子：
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作者：
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