Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis.
Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis.
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DOI：
10.1016/j.nbd.2010.02.005
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发表时间：
2010-07
影响因子：
6.1
通讯作者：
Mehler MF
中科院分区：
文献类型：
--
作者：
Qureshi IA;Mehler MF
表观遗传学和表观基因组医学的迅速崛起有望揭示癫痫疾病的易感性和发病与进展的新见解。表观遗传调节机制现在涉及神经发育的协调方面（例如，细胞命运特化和成熟），稳态和应激反应（例如，立即早期基因转录），和神经网络功能（例如，兴奋-抑制偶联和活性依赖性可塑性）。这些相同的神经生物学过程负责确定复杂癫痫疾病状态的异质性特征。因此，我们强调了最近的证据，开始阐明表观遗传机制，包括DNA甲基化，组蛋白编码修饰和染色质重塑，非编码RNA和RNA编辑，在人类癫痫综合征和癫痫发生过程中发挥的特定作用。表观基因组的高度整合层负责基因和功能基因网络的细胞类型特异性和精细环境响应性部署，所述基因和功能基因网络是癫痫及其相关共病的分子病理生理学的基础，包括但不限于神经递质受体（例如，GluR 2、GLRA 2和GLRA 3）、生长因子（例如，BDNF）、细胞外基质蛋白（例如，和多种转录调节因子（例如，CREB、c-fos和c-jun）。这些重要的观察结果表明，未来的表观遗传学研究是必要的，以更好地了解，分类，预防和治疗癫痫疾病。
The rapidly emerging science of epigenetics and epigenomic medicine promises to reveal novel insights into the susceptibility to and the onset and progression of epileptic disorders. Epigenetic regulatory mechanisms are now implicated in orchestrating aspects of neural development (e.g., cell fate specification and maturation), homeostasis and stress responses (e.g., immediate early gene transcription), and neural network function (e.g., excitation-inhibition coupling and activity-dependent plasticity). These same neurobiological processes are responsible for determining the heterogeneous features of complex epileptic disease states. Thus, we highlight recent evidence that is beginning to elucidate the specific roles played by epigenetic mechanisms, including DNA methylation, histone code modifications and chromatin remodeling, non-coding RNAs and RNA editing, in human epilepsy syndromes and in the process of epileptogenesis. The highly integrated layers of the epigenome are responsible for the cell type specific and exquisitely environmentally responsive deployment of genes and functional gene networks that underlie the molecular pathophysiology of epilepsy and its associated co-morbidities, including but not limited to neurotransmitter receptors (e.g, GluR2, GLRA2, and GLRA3), growth factors (e.g, BDNF), extracellular matrix proteins (e.g., RELN) and diverse transcriptional regulators (e.g., CREB, c-fos, and c-jun). These important observations suggest that future epigenetic studies are necessary to better understand, classify, prevent and treat epileptic disorders.
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影响因子：
4.1
作者：
Cheever A;Ceman S
通讯作者：
Ceman S
影响因子：
3.7
作者：
Abrajano JJ;Qureshi IA;Gokhan S;Zheng D;Bergman A;Mehler MF
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Mehler MF
影响因子：
5.6
作者：
Deutsch, Stephen I.;Rosse, Richard B.;Mastropaolo, John
通讯作者：
Mastropaolo, John
影响因子：
56.9
作者：
BRUSA, R;ZIMMERMANN, F;SPRENGEL, R
通讯作者：
SPRENGEL, R
影响因子：
12.3
作者：
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通讯作者：
Stratton MR