Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway.
Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway.
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DOI：
10.4161/rna.6.2.8196
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发表时间：
2009-04
期刊：
影响因子：
4.1
通讯作者：
Ceman S
中科院分区：
文献类型：
--
作者：
Cheever A;Ceman S
小的基因组编码的microRNA是mRNA翻译调控中的重要因素。虽然它们的生物起源相对明确，但仍不清楚它们如何被招募到其mRNA靶点。脆性X智力低下蛋白家族成员FMRP、FXR1P和FXR2P是调节其货物mRNA翻译的RNA结合蛋白。所有这三种蛋白质，除了单一的果蝇直系同源物dFmrp外，在物理和功能上都与microRNA通路相关。在这篇综述中，我们总结了什么是已知的脆性X家族成员在翻译调控中的作用，并强调他们与microRNA途径的关联证据。此外，我们提出了一个新的模型磷酸化对FMRP功能的作用，其中FMRP的磷酸化抑制Dicer结合，导致前体microRNA的积累和可能缺乏激活microRNA。
Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FXR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation and highlight evidence for their association with the microRNA pathway. In addition, we present a new model for the role of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.
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