Development of the Centrifugal Blood Pump for a Hybrid Continuous Flow Pediatric Total Artificial Heart: Model, Make, Measure.
Development of the Centrifugal Blood Pump for a Hybrid Continuous Flow Pediatric Total Artificial Heart: Model, Make, Measure.
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DOI：
10.3389/fcvm.2022.886874
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发表时间：
2022
影响因子：
3.6
通讯作者：
Throckmorton, Amy L.
中科院分区：
文献类型：
--
作者：
Fox, Carson S.;Palazzolo, Thomas;Hirschhorn, Matthew;Stevens, Randy M.;Rossano, Joseph;Day, Steven W.;Tchantchaleishvili, Vakhtang;Throckmorton, Amy L.
关键词：
临床上可用于儿科患者的血泵和全人工心脏仍然远远落后于成人。我们正在开发一种混合，连续流动，磁悬浮，小儿全人工心脏（TAH）。混合TAH设计将轴向和离心血泵集成在一个紧凑的外壳内。离心泵围绕单独的轴流泵域旋转，并且两个叶轮围绕共同的中心轴线旋转。在这里，我们集中我们的开发工作的离心血泵通过执行计算流体动力学（CFD）分析的血液流经泵。我们还进行了瞬态CFD分析（准稳态和瞬态旋转滑动界面），以评估泵的动态性能条件。通过建模，我们估计的压力产生，标量应力水平，和流体力施加在磁悬浮叶轮。为了进一步开发离心泵，我们还构建了磁支撑原型，并在体外液压流动回路中进行了测试，并使用牛血进行了4小时血袋溶血研究（n = 6）。磁悬浮离心原型在0-182 mmHg下以2，750 - 4，250 RPM输送0-6.75 L/min。计算预测的压力-流量性能结果低于通过测试测量的结果;发现轴向和径向流体力<3 N，并且预测机械功率使用<5 W。血液损伤指数（幂律加权暴露时间和标量应力）<2%。所有数据趋势均符合离心泵设计的预期。在准稳态和瞬态模拟中观察到六个压力升高峰值，与六叶片叶轮的叶片通过频率相关。平均N.I. H值（n = 6）确定为0.09 ± 0.02 g/100 L，高于预期值，必须通过设计改进解决。这些数据为下一个开发阶段奠定了坚实的基础，我们将在此阶段集成轴流泵组件。
Clinically-available blood pumps and total artificial hearts for pediatric patients continue to lag well behind those developed for adults. We are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). The hybrid TAH design integrates both an axial and centrifugal blood pump within a single, compact housing. The centrifugal pump rotates around the separate axial pump domain, and both impellers rotate around a common central axis. Here, we concentrate our development effort on the centrifugal blood pump by performing computational fluid dynamics (CFD) analysis of the blood flow through the pump. We also conducted transient CFD analyses (quasi-steady and transient rotational sliding interfaces) to assess the pump's dynamic performance conditions. Through modeling, we estimated the pressure generation, scalar stress levels, and fluid forces exerted on the magnetically levitated impellers. To further the development of the centrifugal pump, we also built magnetically-supported prototypes and tested these in an in vitro hydraulic flow loop and via 4-h blood bag hemolytic studies (n = 6) using bovine blood. The magnetically levitated centrifugal prototype delivered 0–6.75 L/min at 0–182 mmHg for 2,750–4,250 RPM. Computations predicted lower pressure-flow performance results than measured by testing; axial and radial fluid forces were found to be <3 N, and mechanical power usage was predicted to be <5 Watts. Blood damage indices (power law weighted exposure time and scalar stress) were <2%. All data trends followed expectations for the centrifugal pump design. Six peaks in the pressure rise were observed in the quasi-steady and transient simulations, correlating to the blade passage frequency of the 6-bladed impeller. The average N.I.H value (n = 6) was determined to be 0.09 ± 0.02 g/100 L, which is higher than desired and must be addressed through design improvement. These data serve as a strong foundation to build upon in the next development phase, whereby we will integrate the axial flow pump component.
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