The use of computational fluid dynamics in the development of ventricular assist devices.
The use of computational fluid dynamics in the development of ventricular assist devices.
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DOI：
10.1016/j.medengphy.2010.10.014
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发表时间：
2011-04
影响因子：
2.2
通讯作者：
Wu ZJ
中科院分区：
文献类型：
--
作者：
Fraser KH;Taskin ME;Griffith BP;Wu ZJ
在过去的四十年里，心血管假体装置领域的进步极大地促进了心脏治疗的快速发展。机械循环辅助的概念是建立在第一个成功的临床应用心肺机体外循环。从那时起，各种各样的设备被开发出来，以取代或辅助心血管系统的病变部件。心室辅助装置（VADs）基本上是机械泵，用于增强或取代衰竭心脏的一个或多个腔室的功能。在vad的开发过程中，计算流体动力学（CFD）是一个很有吸引力的工具，它允许在不制造物理设备的情况下，在各种操作条件下，对许多不同的设计进行虚拟的功能性能表征。然而，VADs在传统上难以模拟的流态中运行；层流与湍流交界处的过渡区。因此，使用了不同的方法，最好的方法是有争议的。除了这些基本的流体动力学问题外，血液还由生物细胞组成。装置引起的生物并发症是VAD使用的严重后果。并发症包括血液损伤（溶血、血细胞活化）、血栓和栓塞。患者需要经常服用抗凝药物，这可能会导致出血。尽管做出了许多努力，但血液损伤模型在VADs数值分析中的应用仍不能令人满意，这严重影响了CFD的全部潜力。本文回顾了目前用于血泵分析的最先进的CFD，包括对迄今为止研究的实际批判性回顾，这应该有助于设备设计人员选择最合适的方法；总结了血液损伤模型及其在CFD中实现的难点；以及目前在知识和未来工作领域的差距。
Progress in the field of prosthetic cardiovascular devices has significantly contributed to the rapid advancements in cardiac therapy during the last four decades. The concept of mechanical circulatory assistance was established with the first successful clinical use of heart-lung machines for cardiopulmonary bypass. Since then a variety of devices have been developed to replace or assist diseased components of the cardiovascular system. Ventricular assist devices (VADs) are basically mechanical pumps designed to augment or replace the function of one or more chambers of the failing heart. Computational Fluid Dynamics (CFD) is an attractive tool in the development process of VADs, allowing numerous different designs to be characterized for their functional performance virtually, for a wide range of operating conditions, without the physical device being fabricated. However, VADs operate in a flow regime which is traditionally difficult to simulate; the transitional region at the boundary of laminar and turbulent flow. Hence different methods have been used and the best approach is debatable. In addition to these fundamental fluid dynamic issues, blood consists of biological cells. Device-induced biological complications are a serious consequence of VAD use. The complications include blood damage (haemolysis, blood cell activation), thrombosis and emboli. Patients are required to take anticoagulation medication constantly which may cause bleeding. Despite many efforts blood damage models have still not been implemented satisfactorily into numerical analysis of VADs, which severely undermines the full potential of CFD. This paper reviews the current state of the art CFD for analysis of blood pumps, including a practical critical review of the studies to date, which should help device designers choose the most appropriate methods; a summary of blood damage models and the difficulties in implementing them into CFD; and current gaps in knowledge and areas for future work.
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影响因子：
0.8
作者：
Anand, M;Rajagopal, KR
通讯作者：
Rajagopal, KR
影响因子：
4.2
作者：
Anderson, JB;Wood, HG;Bearnson, G
通讯作者：
Bearnson, G
DOI：
10.1243/09544119jeim352
发表时间：
2008-05-01
影响因子：
1.8
作者：
Antaki, J. F.;Diao, C-G;Kameneva, M. V.
通讯作者：
Kameneva, M. V.
影响因子：
2.4
作者：
Burgreen, GW;Loree, HM;Schöb, R
通讯作者：
Schöb, R
影响因子：
2.4
作者：
Burgreen, GW;Antaki, JF;Holmes, AJ
通讯作者：
Holmes, AJ