Genetic Overlap Between Midfrontal Theta Signals and Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Longitudinal Twin Cohort.
Genetic Overlap Between Midfrontal Theta Signals and Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Longitudinal Twin Cohort.
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DOI：
10.1016/j.biopsych.2023.05.006
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发表时间：
2023-11-15
影响因子：
10.6
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中科院分区：
文献类型：
--
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认知控制与中额波（4-8赫兹）的大脑活动密切相关。这种控制过程已知在患有精神疾病和神经发育诊断的个体中受损，包括注意缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）。尤其是θ波的时间变异性与多动症有关，共同的遗传变异是这种关系的基础。在此，我们在一项针对年轻人的大型双胞胎研究中纵向研究了theta相位变异性、theta相关信号（N2、错误相关的负性和错误正性）、反应时间以及ADHD和ASD之间的表型和遗传关系，以研究这些测量之间随时间的遗传关系的稳定性。遗传多元责任阈值模型在566名参与者（283对双胞胎）的纵向样本上运行。在儿童期和青年期测量ADHD和ASD的特征，而在青年期在箭头侧翼任务期间记录脑电图。成年期的交叉试验θ期变异性与反应时间变异性以及儿童和成人ADHD特征之间存在显著的正表型和遗传关系。误差阳性幅度在两个时间点与ADHD和ASD均呈表型和遗传负相关。我们发现在信号变异性和多动症之间存在显著的遗传关联。当前研究的一个新发现是，这些关系随着时间的推移是稳定的，这表明ADHD控制过程的时间协调的核心失调持续存在于有儿童症状的个体中。错误处理在ADHD和ASD中都发生了改变，有很强的遗传作用。
Cognitive control has been strongly linked to midfrontal theta (4–8 Hz) brain activity. Such control processes are known to be impaired in individuals with psychiatric conditions and neurodevelopmental diagnoses, including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Temporal variability in theta, in particular, has been associated with ADHD, with shared genetic variance underlying the relationship. Here, we investigated the phenotypic and genetic relationships between theta phase variability, theta-related signals (the N2, error-related negativity, and error positivity), reaction time, and ADHD and ASD longitudinally in a large twin study of young adults to investigate the stability of the genetic relationships between these measures over time. Genetic multivariate liability threshold models were run on a longitudinal sample of 566 participants (283 twin pairs). Characteristics of ADHD and ASD were measured in childhood and young adulthood, while an electroencephalogram was recorded in young adulthood during an arrow flanker task. Cross-trial theta phase variability in adulthood showed large positive phenotypic and genetic relationships with reaction time variability and both childhood and adult ADHD characteristics. Error positivity amplitude was negatively related phenotypically and genetically to ADHD and ASD at both time points. We showed significant genetic associations between variability in theta signaling and ADHD. A novel finding from the current study is that these relationships were stable across time, indicating a core dysregulation of the temporal coordination of control processes in ADHD that persists in individuals with childhood symptoms. Error processing, indexed by the error positivity, was altered in both ADHD and ASD, with a strong genetic contribution.
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影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
1.7
作者：
Adler, L;Cohen, J
通讯作者：
Cohen, J
影响因子：
3
作者：
Adamo, Nicoletta;Di Martino, Adriana;Zuddas, Alessandro
通讯作者：
Zuddas, Alessandro
影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
3
作者：
Asherson, Philip;Akehurst, Ron;Hodgkins, Paul
通讯作者：
Hodgkins, Paul