Clinical review: oxygen as a signaling molecule.
Clinical review: oxygen as a signaling molecule.
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临床综述：氧作为信号分子。
DOI：
10.1186/cc9185
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Piantadosi CA
中科院分区：
文献类型：
--
作者：
Bartz RR;Piantadosi CA
显然，分子氧对于以有氧生命可用的形式保存能量至关重要。然而，它的利用是有代价的——活性氧（ROS）的产生。 ROS 对一系列生物大分子具有高度破坏性，过去，这些短命分子在各种疾病状态下的过量产生被认为只对细胞和组织（如肺）有毒。然而，最近的基础研究表明，ROS 的产生，特别是过氧化氢的产生，在细胞内和细胞外信号转导中发挥着重要作用，涉及从血管健康到宿主防御的多种功能。本综述总结了氧通过其反应中间体发挥作用，招募酶促抗氧化防御、刺激细胞修复过程和减轻细胞损伤的能力。
Molecular oxygen is obviously essential for conserving energy in a form useable for aerobic life; however, its utilization comes at a cost - the production of reactive oxygen species (ROS). ROS can be highly damaging to a range of biological macromolecules, and in the past the overproduction of these short-lived molecules in a variety of disease states was thought to be exclusively toxic to cells and tissues such as the lung. Recent basic research, however, has indicated that ROS production - in particular, the production of hydrogen peroxide - plays an important role in both intracellular and extracellular signal transduction that involves diverse functions from vascular health to host defense. The present review summarizes oxygen's capacity, acting through its reactive intermediates, to recruit the enzymatic antioxidant defenses, to stimulate cell repair processes, and to mitigate cellular damage.
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影响因子：
7.4
作者：
Circu, Magdalena L.;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
影响因子：
2.9
作者：
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通讯作者：
FAHIMI, HD
DOI：
10.1111/j.1749-6632.1998.tb09905.x
发表时间：
1998-01-01
期刊：
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影响因子：
--
作者：
Barja, G
通讯作者：
Barja, G
影响因子：
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作者：
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通讯作者：
Jackson, Malcolm J.
影响因子：
4.8
作者：
Gotoh, Y;Cooper, JA
通讯作者：
Cooper, JA