Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014.

Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014.
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DOI:
10.1192/bjp.bp.117.202606
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发表时间:
2017-09
期刊:
The British journal of psychiatry : the journal of mental science
影响因子:
--
通讯作者:
Osborn DPJ
Osborn DPJ
中科院分区:
其他
文献类型:
--
作者:
Hayes JF;Marston L;Walters K;King MB;Osborn DPJ

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背景双相情感障碍和精神分裂症与死亡率相对于一般人群增加有关。国际上都强调降低这种过高的死亡率。目的确定双相情感障碍和精神分裂症患者与普通人群之间的死亡率差距是否缩小。一项全国代表性队列研究,使用2000年至2014年的初级保健电子健康记录,比较所有诊断为双相情感障碍或精神分裂症的患者和普通人群。主要结局为全因死亡率。结果双相情感障碍和精神分裂症患者的死亡率较高(校正后的危险比(HR)分别为1.79,95% CI 1.67-1.88和2.08,95% CI 1.98-2.19)。从2006年到2014年,双相情感障碍的校正HR增加了0.14/年(95% CI 0.10-0.19)。精神分裂症的校正HR从2004年至2010年逐渐增加(0.11/年,95%CI 0.04-0.17),2010年后迅速增加(0.34/年,95%CI 0.18-0.49)。结论双相情感障碍和精神分裂症患者与普通人群之间的死亡率差距正在扩大。
Background Bipolar disorder and schizophrenia are associated with increased mortality relative to the general population. There is an international emphasis on decreasing this excess mortality. Aims To determine whether the mortality gap between individuals with bipolar disorder and schizophrenia and the general population has decreased. Method A nationally representative cohort study using primary care electronic health records from 2000 to 2014, comparing all patients diagnosed with bipolar disorder or schizophrenia and the general population. The primary outcome was all-cause mortality. Results Individuals with bipolar disorder and schizophrenia had elevated mortality (adjusted hazard ratio (HR) = 1.79, 95% CI 1.67–1.88 and 2.08, 95% CI 1.98–2.19 respectively). Adjusted HRs for bipolar disorder increased by 0.14/year (95% CI 0.10–0.19) from 2006 to 2014. The adjusted HRs for schizophrenia increased gradually from 2004 to 2010 (0.11/year, 95% CI 0.04–0.17) and rapidly after 2010 (0.34/year, 95% CI 0.18–0.49). Conclusions The mortality gap between individuals with bipolar disorder and schizophrenia, and the general population is widening.
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