Spatiotemporal control of pattern formation during somitogenesis.
Spatiotemporal control of pattern formation during somitogenesis.
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DOI：
10.1126/sciadv.adk8937
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发表时间：
2024-01-26
期刊：
影响因子：
13.6
通讯作者：
Ozbudak, Ertugrul M.
中科院分区：
文献类型：
--
作者：
Mcdaniel, Cassandra;Simsek, M. Fethullah;Chandel, Angad Singh;Ozbudak, Ertugrul M.
时空模式广泛存在于生物、化学和物理系统中。特别是，胚胎发育表现出在许多组织和器官中建立的多种重复模式。肺、肾、肝、胰腺和乳腺中的分支树状结构以及附肢、牙齿和腭中的手指和骨骼只是几个例子。重复图案的一个有趣的例子是主要身体轴的顺序分割，这在所有脊椎动物以及许多节肢动物和环节动物中都是保守的。在这些物种中，体轴在包含未分段组织的胚胎后端伸长。与此同时，片段依次从未分段组织的前端萌芽，形成精致的重复图案并创建分段的身体计划。在脊椎动物中，近轴中胚层依次分为体节。在这篇综述中，我们将讨论脊椎动物体节分割中最突出的模型、最令人费解的实验数据和突出的问题。全面综述探讨了脊椎动物体节分割领域的模型、数据和突出问题。
Spatiotemporal patterns widely occur in biological, chemical, and physical systems. Particularly, embryonic development displays a diverse gamut of repetitive patterns established in many tissues and organs. Branching treelike structures in lungs, kidneys, livers, pancreases, and mammary glands as well as digits and bones in appendages, teeth, and palates are just a few examples. A fascinating instance of repetitive patterning is the sequential segmentation of the primary body axis, which is conserved in all vertebrates and many arthropods and annelids. In these species, the body axis elongates at the posterior end of the embryo containing an unsegmented tissue. Meanwhile, segments sequentially bud off from the anterior end of the unsegmented tissue, laying down an exquisite repetitive pattern and creating a segmented body plan. In vertebrates, the paraxial mesoderm is sequentially divided into somites. In this review, we will discuss the most prominent models, the most puzzling experimental data, and outstanding questions in vertebrate somite segmentation. A comprehensive review explores models, data, and outstanding questions in the field of vertebrate somite segmentation.
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