'Manipulation' without the parasite: altered feeding behaviour of mosquitoes is not dependent on infection with malaria parasites.
'Manipulation' without the parasite: altered feeding behaviour of mosquitoes is not dependent on infection with malaria parasites.
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DOI：
10.1098/rspb.2013.0711
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发表时间：
2013-07-22
期刊：
影响因子：
--
通讯作者：
Thomas MB
中科院分区：
文献类型：
--
作者：
Cator LJ;George J;Blanford S;Murdock CC;Baker TC;Read AF;Thomas MB
先前的研究表明，疟原虫可以操纵蚊子的进食行为，如探测，持久性和饱食率，以提高传播成功率。在这里，我们扩大分析这种“操纵表型”考虑接近觅食行为，包括响应主机气味和主机位置。使用斯氏按蚊和约氏疟原虫作为模型系统，我们表明，蚊子与早期感染（即非感染性卵囊）表现出对人类宿主的吸引力降低，而那些与晚期感染（即感染性子孢子）表现出增加的吸引力。这些阶段特异性的行为变化被蚊子气味受体反应性的变化所掩盖，为这些反应提供了可能的神经生理机制。然而，我们还发现，行为和神经生理学变化都可以通过热灭活大肠杆菌的免疫攻击产生，因此与疟疾寄生虫的存在没有明确的联系。我们的研究结果支持这一假设，雌性蚊子的喂养行为被疟原虫改变，但问题的程度，这是由于主动操纵宿主行为的疟原虫。
Previous studies have suggested that Plasmodium parasites can manipulate mosquito feeding behaviours such as probing, persistence and engorgement rate in order to enhance transmission success. Here, we broaden analysis of this ‘manipulation phenotype’ to consider proximate foraging behaviours, including responsiveness to host odours and host location. Using Anopheles stephensi and Plasmodium yoelii as a model system, we demonstrate that mosquitoes with early stage infections (i.e. non-infectious oocysts) exhibit reduced attraction to a human host, whereas those with late-stage infections (i.e. infectious sporozoites) exhibit increased attraction. These stage-specific changes in behaviour were paralleled by changes in the responsiveness of mosquito odourant receptors, providing a possible neurophysiological mechanism for the responses. However, we also found that both the behavioural and neurophysiological changes could be generated by immune challenge with heat-killed Escherichia coli and were thus not tied explicitly to the presence of malaria parasites. Our results support the hypothesis that the feeding behaviour of female mosquitoes is altered by Plasmodium, but question the extent to which this is owing to active manipulation by malaria parasites of host behaviour.
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DOI：
10.1080/00034983.1990.11812510
发表时间：
1990-12-01
影响因子：
--
作者：
LINDSAY, SW;CAMPBELL, H;GREENWOOD, BM
通讯作者：
GREENWOOD, BM
DOI：
10.4269/ajtmh.1984.33.17
发表时间：
1984-01-01
影响因子：
3.3
作者：
ROSSIGNOL, PA;RIBEIRO, JMC;SPIELMAN, A
通讯作者：
SPIELMAN, A
影响因子：
2.4
作者：
Koella, JC;Rieu, L;Paul, REL
通讯作者：
Paul, REL
影响因子：
2.2
作者：
Takken, W;van Loon, JJA;Adam, W
通讯作者：
Adam, W
影响因子：
1
作者：
Takken, W;Dekker, T;Wijnholds, YG
通讯作者：
Wijnholds, YG