Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure.
Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure.
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纳米颗粒吸入暴露后全身健康结果的间接中介。
DOI：
10.1016/j.pharmthera.2022.108120
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发表时间：
2022-07
影响因子：
13.5
通讯作者：
Ottens, Andrew K.
中科院分区：
文献类型：
--
作者：
Mostovenko, Ekaterina;Canal, Christopher G.;Cho, MiJin;Sharma, Kirti;Erdely, Aaron;Campen, Matthew J.;Ottens, Andrew K.
不断发展的纳米科学领域揭示了纳米颗粒的自然和人为来源的广泛多样性，引起了人们对其对人类健康影响的关注。吸入是最强劲的进入途径，纳米颗粒(NPs)避开粘液纤毛清除，沉积到肺泡区深处。然而，吸入NPs的影响明显超出肺的范围，特别是对心血管系统和大脑等高度血运器官的影响。外周效应的部分原因是一些NPs从肺转移到循环中；然而，其他主要局限于肺的NPs仍然伴随着全身性后果。组学研究才刚刚开始，关于肺部病理副产品从肺释放到血液的无数复杂分子的信息。这些间接介体在其分子组成和在外围的活性方面是不同的。本文综述了肺内NP暴露引起的全身后果，以及从肺释放到循环中的间接病理介质的已知情况。进一步的关注点是大脑的结果，这是一个高度血管化的区域，容易受到急性和长期结果的影响。这里的发现支持大数据毒理学研究的必要性，以了解是什么驱动了这些健康结果，并更好地预测、规避和治疗由NP暴露情景产生的潜在健康影响。
The growing field of nanoscience has shed light on the wide diversity of natural and anthropogenic sources of nano-scale particulates, raising concern as to their impacts on human health. Inhalation is the most robust route of entry, with nanoparticles (NPs) evading mucociliary clearance and depositing deep into the alveolar region. Yet, impacts from inhaled NPs are evident far outside the lung, particularly on the cardiovascular system and highly vascularized organs like the brain. Peripheral effects are partly explained by the translocation of some NPs from the lung into the circulation; however, other NPs largely confined to the lung are still accompanied by systemic outcomes. Omic research has only just begun to inform on the complex myriad of molecules released from the lung to the blood as byproducts of pulmonary pathology. These indirect mediators are diverse in their molecular make-up and activity in the periphery. The present review examines systemic outcomes attributed to pulmonary NP exposure and what is known about indirect pathological mediators released from the lung into the circulation. Further focus was directed to outcomes in the brain, a highly vascularized region susceptible to acute and longer-term outcomes. Findings here support the need for big-data toxicological studies to understand what drives these health outcomes and better predict, circumvent, and treat the potential health impacts arising from NP exposure scenarios.
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由多壁碳纳米管暴露引起的MMP-9依赖性血清传播生物活性通过CD36清道夫受体诱导血管功能障碍。
DOI：
10.1093/toxsci/kfw015
发表时间：
2016-04
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Aragon M;Erdely A;Bishop L;Salmen R;Weaver J;Liu J;Hall P;Eye T;Kodali V;Zeidler-Erdely P;Stafflinger JE;Ottens AK;Campen MJ
通讯作者：
Campen MJ
影响因子：
3.5
作者：
Al-Lozi A;Nielsen SS;Hershey T;Birke A;Checkoway H;Criswell SR;Racette BA
通讯作者：
Racette BA
影响因子：
15.1
作者：
Bolton, Jessica L.;Auten, Richard L.;Bilbo, Staci D.
通讯作者：
Bilbo, Staci D.
影响因子：
2.5
作者：
Becheri, Alessio;Durr, Maximilian;Baglioni, Piero
通讯作者：
Baglioni, Piero
影响因子：
3.4
作者：
Bailey, Lisa A.;Kerper, Laura E.;Goodman, Julie E.
通讯作者：
Goodman, Julie E.