Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection.
Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection.
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DOI：
10.1016/j.rmed.2020.106276
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发表时间：
2021-01
影响因子：
4.3
通讯作者：
Vanderhelst E
中科院分区：
文献类型：
--
作者：
Smet J;Stylemans D;Hanon S;Ilsen B;Verbanck S;Vanderhelst E
由于有关 COVID-19 后临床状况的研究很少，我们进行了一项横断面研究，评估残留症状、肺功能和胸部 CT。在门诊随访期间，诊断后约 10 周评估胸部 CT、肺功能和 COVID-19 相关症状。从患者档案中收集人口统计数据、基线（诊断时间）CT 评分和血液结果。分析了肺功能与临床特征（基线）、血液标记物（基线）、胸部 CT（基线和随访）和症状评分（随访）之间的关联。使用Mann-Whitney U检验和卡方检验对有和没有限制的亚组之间进行统计比较。中位随访时间为 74±12 (SD) 天，对 220 名受试者进行了评估。随访时中位症状和中位CT评分分别为1（IQR=0-2）和2（IQR=0-6）。 46% 的患者肺功能正常，而 38% 和 22% 的受试者的 TLC 和 TLCO 低于正常下限。这种限制性肺损伤与住院时间（8 天 vs 6 天；p=0.003）、入住重症监护室（27% vs 13%；p=0.009）和有创机械通气（10% vs 0.7%；p=0.001）相关，但与基线和随访时的症状评分或 CT 评分无关。 54% 的 COVID-19 幸存者在诊断后 10 周出现肺功能异常。限制是最普遍的肺功能，病情越危重的患者更容易出现这种情况。然而，限制与异常影像结果或残留症状无关。
Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study with assessment of residual symptoms, lung function and chest CT. During an outpatient follow-up visit, chest CT, pulmonary function and COVID-19 related symptoms were assessed approximately 10 weeks after diagnosis. Demographics, baseline (time of diagnosis) CT score and blood results were collected from patient files. Association between lung function and clinical characteristics (baseline), blood markers (baseline), chest CT (baseline and follow-up) and symptom score (followup) was analysed. Mann-Whitney U tests and Chi squared tests were used for statistical comparison between subgroups with and without restriction. Two hundred-twenty subjects were evaluated at a median follow-up of 74±12 (SD) days. Median symptom and median CT score at follow-up were 1(IQR=0- 2) and 2(IQR=0-6) respectively. Forty-six percent of patients had normal lung function, while TLC and TLCO below the lower limit of normal were observed in 38% and 22% of subjects respectively. This restrictive pulmonary impairment was associated with length of hospital stay (8 vs 6 days; p=0.003), admission to the intensive care unit (27% vs 13%;p=0.009), and invasive mechanical ventilation (10% vs 0.7%;p=0.001), but not with symptom score or CT score at baseline and follow-up. Fifty-four percent of COVID-19 survivors had abnormal lung function 10 weeks after diagnosis. Restriction was the most prevalent pulmonary function, with the more critically ill patients being more prone to this condition. Yet, restriction could not be linked with abnormal imaging results or residual symptoms.
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3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
影响因子：
15.1
作者：
Zhao, Yu-miao;Shang, Yao-min;Xu, Ai-guo
通讯作者：
Xu, Ai-guo
影响因子：
24.3
作者：
Verbanck, Sylvia;Van Muylem, Alain;Vincken, Walter
通讯作者：
Vincken, Walter
影响因子：
19.7
作者：
Pan, Feng;Ye, Tianhe;Zheng, Chuansheng
通讯作者：
Zheng, Chuansheng
影响因子：
3.7
作者：
Verbanck, Sylvia;Schuermans, Daniel;Vanderhelst, Eef
通讯作者：
Vanderhelst, Eef