Structural magnetic resonance image averaging in schizophrenia.
Structural magnetic resonance image averaging in schizophrenia.
复制标题
精神分裂症的结构磁共振图像平均。
DOI：
--
复制
发表时间：
1998
影响因子：
17.7
通讯作者：
John Rotrosen
中科院分区：
文献类型：
--
作者：
A. Wolkin;Henry Rusinek;Gita Vaid;L. Arena;T. Lafargue;M. Sanfilipo;Celia Loneragan;A. Lautin;John Rotrosen
OBJECTIVE
Intersubject averaging of structural magnetic resonance (MR) images has been infrequently used as a means to study group differences in cerebral structure throughout the brain. In the present study, the authors used linear intersubject averaging of structural MR images to evaluate the validity and utility of this technique and to extend previous research, conducted using a different approach to image averaging, in which reduction in thalamic size and abnormalities in perithalamic white matter tracts in the brains of schizophrenic patients were reported by Andreasen et al.
METHOD
A 1.5-T MR scanner was used to obtain high-resolution, whole brain T1-weighted structural MR images for an age-matched sample of 25 schizophrenic patients and 25 normal control subjects. A "bounding box" procedure was used to create a single "averaged" brain for the schizophrenic group and for the control group. Differences in signal intensity between the two average brains were examined on a pixel-wise basis through use of one-tailed effect size maps.
RESULTS
Effect size maps revealed widespread patchy signal intensity differences between the two groups in both cortical and periventricular areas, including major white matter tracts. The signal intensity differences were consistent with cortical thinning/sulcal widening and ventricular enlargement. No differences were found within thalamus or in immediately surrounding white matter. Effect size maps for differences (schizophrenic minus normal subjects) had only small values.
CONCLUSIONS
These results are consistent with diffuse structural brain abnormalities of both gray and white matter in schizophrenic populations such as the one in this study.
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DOI：
10.1056/nejm199003223221201
发表时间：
1990-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
R. Suddath;G. Christison;E. Torrey;M. Casanova;D. Weinberger
通讯作者：
R. Suddath;G. Christison;E. Torrey;M. Casanova;D. Weinberger
精神分裂症的左颞叶异常和思维障碍。
DOI：
10.1056/nejm199208273270905
发表时间：
1992
期刊：
The New England journal of medicine
影响因子：
--
作者：
Shenton,ME;Kikinis,R;Jolesz,FA;Pollak,SD;LeMay,M;Wible,CG;Hokama,H;Martin,J;Metcalf,D;Coleman,M
通讯作者：
Coleman,M
精神分裂症额叶系统的结构异常。
影响因子：
--
作者：
Andreasen,N;Nasrallah,HA;Dunn,V;Olson,SC;Grove,WM;Ehrhardt,JC;Coffman,JA;Crossett,JH
通讯作者：
Crossett,JH
影响因子：
1.9
作者：
E. Minkov;A. Novick-Cohen
通讯作者：
E. Minkov;A. Novick-Cohen
DOI：
10.1176/ajp.147.11.1457
发表时间：
1990
期刊：
The American journal of psychiatry
影响因子：
--
作者：
P. Barta;G. Pearlson;R. Powers;S. S. Richards-S.;L. Tune
通讯作者：
P. Barta;G. Pearlson;R. Powers;S. S. Richards-S.;L. Tune