The impact of visual acuity on age-related differences in neural markers of early visual processing.
The impact of visual acuity on age-related differences in neural markers of early visual processing.
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DOI：
10.1016/j.neuroimage.2012.10.089
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发表时间：
2013-02-15
期刊：
影响因子：
5.7
通讯作者：
Holcomb, Phillip J.
中科院分区：
文献类型：
--
作者：
Daffner, Kirk R.;Haring, Anna E.;Alperin, Brittany R.;Zhuravleva, Tatyana Y.;Mott, Katherine K.;Holcomb, Phillip J.
视觉处理的神经标记物的年龄相关差异在多大程度上受到视敏度变化的影响尚未得到系统的研究。研究通常表明，他们的受试者有正常或矫正到正常的视力，但视力的评估似乎最常见的是仅基于自我报告。与之前的研究一致，要纳入本研究，受试者必须报告正常或矫正至正常的视力。此外，使用Snellen视力表正式测试视力。研究了年轻人（18-32岁）、老年人（65-79岁）和老年人（80岁以上）在进行涉及选择性注意颜色的视觉处理任务时的事件相关电位（ERP）。研究了早期视觉处理的ERP标记物（后P1和N1成分）的潜伏期和振幅的差异。在控制视力后，对所有结果进行重新分析。我们发现视敏度随着年龄的增长而下降。考虑视力对老年人和年轻人是否在后P1和N1分量的大小和潜伏期方面存在显著差异有影响。在控制视力后，与年龄相关的P1和N1潜伏期增加并不显著，老年人的P1振幅比年轻人大。我们的研究结果表明，直到年龄相关的视力差异和早期ERP之间的关系是明确的，研究人员应谨慎解释他们的研究结果的意义。关于视力的自我报告可能是不准确的，需要正式的措施。需要进一步的调查，以帮助建立指导方针，为未来的研究，特别是非常老年人。
The extent to which age-related differences in neural markers of visual processing are influenced by changes in visual acuity has not been systematically investigated. Studies often indicate that their subjects had normal or corrected-to-normal vision, but the assessment of visual acuity seems to most frequently be based only on self-report. Consistent with prior research, to be included in the current study, subjects had to report normal or corrected-to-normal vision. Additionally, visual acuity was formally tested using a Snellen eye chart. Event-related potentials (ERPs) were studied in young adults (18–32 years old), young-old adults (65–79 years old), and old-old adults (80+ years old) while they performed a visual processing task involving selective attention to color. Age-related differences in the latency and amplitude of ERP markers of early visual processing, the posterior P1 and N1 components, were examined. All results were then re-analyzed after controlling for visual acuity. We found that visual acuity declined as a function of age. Accounting for visual acuity had an impact on whether older and younger adults differed significantly in the size and latency of the posterior P1 and N1 components. After controlling for visual acuity, age-related increases in P1 and N1 latency did not remain significant, and older adults were found to have a larger P1 amplitude than young adults. Our results suggest that until the relationship between age-associated differences in visual acuity and early ERPs is clearly established, investigators should be cautious when interpreting the meaning of their findings. Self-reports about visual acuity may be inaccurate, necessitating formal measures. Additional investigation is needed to help establish guidelines for future research, especially of very old adults.
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影响因子：
2.9
作者：
Daffner KR;Tarbi EC;Haring AE;Zhuravleva TY;Sun X;Rentz DM;Holcomb PJ
通讯作者：
Holcomb PJ
影响因子：
--
作者：
CELESIA, GG;DALY, RF
通讯作者：
DALY, RF
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
2.6
作者：
Curran, T;Hills, A;Strauss, ME
通讯作者：
Strauss, ME
影响因子：
4.2
作者：
DUSTMAN, RE;SNYDER, EW
通讯作者：
SNYDER, EW