Cell fusion in the brain: two cells forward, one cell back.
Cell fusion in the brain: two cells forward, one cell back.
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DOI：
10.1007/s00401-014-1303-1
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发表时间：
2014-11
影响因子：
12.7
通讯作者：
Scolding N
中科院分区：
文献类型：
--
作者：
Kemp K;Wilkins A;Scolding N
成体干细胞群，特别是那些存在于骨髓中的干细胞群，已被证明对啮齿动物和人类大脑中的几种神经元细胞类型有贡献。循环骨髓细胞可以迁移到中枢神经系统并与特别是小脑浦肯野细胞融合的观察结果至少部分地表明了这一过程背后的潜在机制。实验表明，大脑中细胞融合的发生率随着年龄、辐射暴露、炎症、化疗药物甚至神经元本身的选择性损伤而增加。通过检测双核神经元的增加表明细胞融合的存在，也已在多种人类中枢神经系统疾病中得到描述，包括多发性硬化症和阿尔茨海默病。因此，越来越多的证据对细胞融合的生物学意义提出了新的问题，它有可能代表细胞介导的神经保护或拯救成年后无法替代的高度复杂神经元的重要手段。在这里，我们讨论了啮齿动物和人类大脑中这种现象背后的证据，重点是随后研究该过程背后的细胞融合的生理机制。我们还强调这些研究如何为内源性神经元修复提供新的见解，为针对神经退行性变和脑损伤的潜在治疗干预开辟新的令人兴奋的途径。
Adult stem cell populations, notably those which reside in the bone marrow, have been shown to contribute to several neuronal cell types in the rodent and human brain. The observation that circulating bone marrow cells can migrate into the central nervous system and fuse with, in particular, cerebellar Purkinje cells has suggested, at least in part, a potential mechanism behind this process. Experimentally, the incidence of cell fusion in the brain is enhanced with age, radiation exposure, inflammation, chemotherapeutic drugs and even selective damage to the neurons themselves. The presence of cell fusion, shown by detection of increased bi-nucleated neurons, has also been described in a variety of human central nervous system diseases, including both multiple sclerosis and Alzheimer’s disease. Accumulating evidence is therefore raising new questions into the biological significance of cell fusion, with the possibility that it represents an important means of cell-mediated neuroprotection or rescue of highly complex neurons that cannot be replaced in adult life. Here, we discuss the evidence behind this phenomenon in the rodent and human brain, with a focus on the subsequent research investigating the physiological mechanisms of cell fusion underlying this process. We also highlight how these studies offer new insights into endogenous neuronal repair, opening new exciting avenues for potential therapeutic interventions against neurodegeneration and brain injury.
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影响因子：
2.9
作者：
MARES, V;LODIN, Z;SACHA, J
通讯作者：
SACHA, J
影响因子：
64.8
作者：
Alvarez-Dolado, M;Pardal, R;Alvarez-Buylla, A
通讯作者：
Alvarez-Buylla, A
影响因子：
6.2
作者：
Nakano, K;Migita, M;Shimada, T
通讯作者：
Shimada, T
DOI：
10.1007/bf00533133
发表时间：
1980-01-01
期刊：
HISTOCHEMISTRY
影响因子：
--
作者：
MARES, V;VANDERPLOEG, M
通讯作者：
VANDERPLOEG, M
影响因子：
3.5
作者：
Chen, K. Amy;Cruz, Pedro E.;Lanuto, Derek J.;Flotte, Terence R.;Borchelt, David R.;Srivastava, Arun;Zhang, Jianyi;Steindler, Dennis A.;Zheng, Tong
通讯作者：
Zheng, Tong