A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
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DOI：
10.1016/j.cccb.2023.100189
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wardlaw, Joanna M
中科院分区：
文献类型：
--
作者：
Sri, Sarmi;Greenstein, Adam;Granata, Alessandra;Collcutt, Alex;Jochems, Angela C C;McColl, Barry W;Castro, Blanca Diaz;Webber, Caleb;Reyes, Carmen Arteaga;Hall, Catherine;Lawrence, Catherine B;Hawkes, Cheryl;Pegasiou-Davies, Chrysia-Maria;Gibson, Claire;Crawford, Colin L;Smith, Colin;Vivien, Denis;McLean, Fiona H;Wiseman, Frances;Brezzo, Gaia;Lalli, Giovanna;Pritchard, Harry A T;Markus, Hugh S;Bravo-Ferrer, Isabel;Taylor, Jade;Leiper, James;Berwick, Jason;Gan, Jian;Gallacher, John;Moss, Jonathan;Goense, Jozien;McMullan, Letitia;Work, Lorraine;Evans, Lowri;Stringer, Michael S;Ashford, Mlj;Abulfadl, Mohamed;Conlon, Nina;Malhotra, Paresh;Bath, Philip;Canter, Rebecca;Brown, Rosalind;Ince, Selvi;Anderle, Silvia;Young, Simon;Quick, Sophie;Szymkowiak, Stefan;Hill, Steve;Allan, Stuart;Wang, Tao;Quinn, Terry;Procter, Tessa;Farr, Tracy D;Zhao, Xiangjun;Yang, Zhiyuan;Hainsworth, Atticus H;Wardlaw, Joanna M
不同的模型概括了人类SVD的不同方面——应该使用正确的模型来回答正确的问题。成功的翻译需要临床前和临床研究人员之间密切的工作关系，以确定连接基础科学和临床的桥梁点。通过prct的概念，需要协调对动物模型进行更严格、稳健和详细的临床前评估。英国DRI血管主题与DPUK实验医学孵化器正在努力建立一个社区，以促进VCI临床前和临床研究。虽然痴呆症研究一直以阿尔茨海默病（AD）为主，但现在认为大多数老年人痴呆症是由混合病理引起的，通常是血管和AD脑病理的结合。血管性认知障碍（VCI）包括血管性痴呆（VaD），是第二常见的痴呆类型。由于对潜在的病因和发病机制的了解有限，VCI的模型被推迟了。本综述由一个多学科、多样化（性别、地理和职业阶段）、跨研究所的团队进行，提供了对当前VCI模型局限性的看法，并提出了改进翻译和可重复性的建议。我们讨论了VCI的可重复性、临床特征和相应的模型评估、人类病理学、生物信息学方法和数据共享。我们对未来的研究提出建议，特别关注作为主要基础疾病的小血管疾病。
Different models recapitulate different aspects of human SVD – the right model should be used to answer the right question. Successful translation requires close-working relationship between preclinical and clinical researchers to identify bridging points linking the basic science to the clinics. Co-ordination of more rigorous, robust, and detailed preclinical evaluation of animal models is required through the concept of pRCTs. The UK DRI vascular Theme, alongside DPUK experimental medicine Incubator, are working towards building a community to boost VCI preclinical and clinical research. Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.
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影响因子：
3.3
作者：
Hanas JS;Hocker JRS;Vannarath CA;Lerner MR;Blair SG;Lightfoot SA;Hanas RJ;Couch JR;Hershey LA
通讯作者：
Hershey LA
影响因子：
3.4
作者：
Sorby-Adams, Annabel J.;Marian, Oana C.;Bilecki, Isabella M.;Elms, Levi E.;Camargo, Jonathan;Hall, Kelly;Crowther, Robert G.;Leonard, Anna V.;Wadsworth, George I.;Spear, Joshua H.;Turner, Renee J.;Jones, Claire F.
通讯作者：
Jones, Claire F.
影响因子：
6.9
作者：
Stringer MS;Lee H;Huuskonen MT;MacIntosh BJ;Brown R;Montagne A;Atwi S;Ramirez J;Jansen MA;Marshall I;Black SE;Zlokovic BV;Benveniste H;Wardlaw JM
通讯作者：
Wardlaw JM
影响因子：
--
作者：
Noor NM;Pett SL;Esmail H;Crook AM;Vale CL;Sydes MR;Parmar MKB
通讯作者：
Parmar MKB