Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome.
Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome.
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DOI：
10.3389/fneur.2014.00124
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发表时间：
2014
影响因子：
3.4
通讯作者：
Cho C
中科院分区：
文献类型：
--
作者：
Dai M;Cohen B;Smouha E;Cho C
在海上旅行后，通常会出现一种持续的摇晃、摇晃和/或颠簸的感觉。相关的症状引起相当大的痛苦。其潜在的神经机制尚不清楚，迄今为止还没有有效的治疗方法。在猴子和人类中的结果表明，MdDS是由前庭眼反射（VOR）在旋转过程中对头部滚动的适应不良引起的。我们研究了24例持续性MdDS受试者（3例男性，21例女性; 19.1 ± 33个月）。物理检查结果包括0.2 Hz的身体振荡，头部在黑暗中左右滚动时的振荡垂直眼球震颤，以及福田踏步试验期间的单侧旋转。我们假设，不适应的摇摆和身体症状可以通过重新适应VOR来减少或消除。受试者在观看旋转的全视野视觉刺激时，通过从一侧到另一侧滚动头部来治疗。24例受试者中有17例平均完全或实质性恢复约1年。6人最初好转，但症状复发。1例受试者对治疗无应答。因此，VOR的再适应导致70%的MdDS受试者治愈或显著改善。我们的结论是，自适应过程与滚动，而旋转负责生产MdDS，症状可以减少或解决通过重新适应VOR。
The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR) to roll of the head during rotation. We studied 24 subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months). Physical findings included body oscillation at 0.2 Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the 24 subjects had a complete or substantial recovery on average for approximately 1 year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.
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影响因子：
2.7
作者：
Cha YH
通讯作者：
Cha YH
DOI：
10.1002/pri.122
发表时间：
1998-01-01
期刊：
Physiotherapy research international : the journal for researchers and clinicians in physical therapy
影响因子：
--
作者：
Bonanni, M;Newton, R
通讯作者：
Newton, R
影响因子：
6
作者：
Cha, Yoon-Hee;Brodsky, Jae;Baloh, Robert W.
通讯作者：
Baloh, Robert W.
影响因子：
--
作者：
Hain, TC;Hanna, PA;Rheinberger, MA
通讯作者：
Rheinberger, MA
影响因子：
--
作者：
GORDON, CR;SPITZER, O;DOWECK, I
通讯作者：
DOWECK, I