Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4: Application of single cell-type lipidomics.
Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4: Application of single cell-type lipidomics.
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DOI：
10.1111/nyas.14907
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发表时间：
2022-12
影响因子：
5.2
通讯作者：
Yassine, Hussein N.
中科院分区：
文献类型：
--
作者：
Asante, Isaac;Louie, Stan;Yassine, Hussein N.
阿尔茨海默病（AD）中未解决的慢性炎症状态本质上与脑脂质的重塑有关。这篇综述强调了携带载脂蛋白 E ε4 等位基因 (APOE4) 对各种脑细胞类型在促进未解决的炎症状态方面的影响。在其对脑脂质的多效性影响中，我们重点关注 APOE4 对 Ca2+ 依赖性磷脂酶 A2 (cPLA2) 的激活及其对大脑中花生四烯酸、二十碳五烯酸和二十二碳六烯酸信号级联的影响。在神经变性过程中，各种脑细胞类型，如星形胶质细胞、小胶质细胞和神经元，与神经血管单元一起形成独特的炎症表型，影响其功能并具有特征性的脂质组学指纹。我们建议，从不同年龄、性别、疾病严重程度阶段以及饮食和遗传背景的大脑中采集的单细胞类型的脂质组学表型可用于探讨神经退行性变的机制。更好地了解脑细胞炎症/脂质反应有望指导 AD 痴呆的营养和药物干预措施的开发。阿尔茨海默病（AD）中未解决的慢性炎症状态本质上与脑脂质的重塑有关。在这篇综述中，我们根据载脂蛋白 E ε4 等位基因 (APOE4) 携带者状态，重点关注具有 AD 遗传风险的人群的脑脂质及其与炎症的关系。我们提供了一些例子来说明饮食和大脑炎症之间的关系如何相互关联。
A chronic state of unresolved inflammation in Alzheimer's disease (AD) is intrinsically involved with the remodeling of brain lipids. This review highlights the effect of carrying the apolipoprotein E ε4 allele (APOE4) on various brain cell types in promoting an unresolved inflammatory state. Among its pleotropic effects on brain lipids, we focus on APOE4’s activation of Ca2+‐dependent phospholipase A2 (cPLA2) and its effects on arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid signaling cascades in the brain. During the process of neurodegeneration, various brain cell types, such as astrocytes, microglia, and neurons, together with the neurovascular unit, develop distinct inflammatory phenotypes that impact their functions and have characteristic lipidomic fingerprints. We propose that lipidomic phenotyping of single cell‐types harvested from brains differing by age, sex, disease severity stage, and dietary and genetic backgrounds can be employed to probe mechanisms of neurodegeneration. A better understanding of the brain cellular inflammatory/lipidomic response promises to guide the development of nutritional and drug interventions for AD dementia. A chronic state of unresolved inflammation in Alzheimer's disease (AD) is intrinsically involved with the remodeling of brain lipids. In this review, we focus on brain lipids and their connection to inflammation in persons at genetic risk for AD based on apolipoprotein E ε4 allele (APOE4) carrier status. We provide examples on how the relationship between diet and brain inflammation are interconnected.
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营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
DOI：
10.1093/brain/awr074
发表时间：
2011-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Beers DR;Henkel JS;Zhao W;Wang J;Huang A;Wen S;Liao B;Appel SH
通讯作者：
Appel SH
影响因子：
2.4
作者：
Last V;Williams A;Werling D
通讯作者：
Werling D
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G