Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets.
Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets.
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DOI：
10.1038/s41598-022-16625-1
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发表时间：
2022-08-01
影响因子：
4.6
通讯作者：
Kusaka, Takashi
中科院分区：
文献类型：
--
作者：
Nakao, Yasuhiro;Nakamura, Shinji;Htun, Yinmon;Mitsuie, Tsutomu;Koyano, Kosuke;Ohta, Kenichi;Konishi, Yukihiko;Miki, Takanori;Ueno, Masaki;Kusaka, Takashi
围产期新生儿缺氧缺血性脑损伤是世界范围内的一个重大问题。在复苏期间，脑血红蛋白氧饱和度（ScO 2）的变化已被确定的近红外光谱（NIRS）。然而，在窒息新生儿中，这些变化与脑损伤之间的关系尚不清楚。三波长近红外时间分辨光谱是近红外光谱的一种先进技术，可用于估计ScO 2和脑血容量（CBV）。在这里，我们研究了在缺氧缺血性损伤后的复苏期间的ScO 2和CBV的变化，以及这些变化之间的关系，在第5天的损伤和组织病理学脑损伤后，使用窒息的仔猪模型。在36头缺氧缺血性损伤的新生仔猪中，对29头进行了分析。在损伤后0、5、10、15和30 min测量ScO 2和CBV。在第5天对脑组织进行组织学评价。ScO 2和CBV在损伤后立即升高，达到峰值，然后保持恒定值。损伤后5 ~ 30 min CBV的增加与组织病理学损伤评分显著相关。但与ScO 2无相关性。总之，缺氧缺血损伤后30分钟内CBV的增加反映了仔猪模型中损伤后第5天的组织病理学脑损伤。
Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship between these changes and brain injury is not known. Three-wavelength near-infrared time-resolved spectroscopy, an advanced technology for NIRS, allows for the estimation of ScO2 and cerebral blood volume (CBV). Here, we studied changes in ScO2 and CBV during the resuscitation period after hypoxic-ischemic insult and the relationship between these changes after insult and histopathological brain injuries on day 5 after insult using an asphyxiated piglet model. Of 36 newborn piglets subjected to hypoxic-ischemic insult, 29 were analyzed. ScO2 and CBV were measured 0, 5, 10, 15, and 30 min after the insult. Brain tissue was histologically evaluated on day 5. ScO2 and CBV increased immediately after the insult, reached a peak, and then maintained a consistent value. The increase in CBV 5 to 30 min after the insult was significantly correlated with histopathological injury scores. However, there was no correlation with ScO2. In conclusion, an increase in CBV within 30 min after hypoxic-ischemic insult reflects the histopathological brain injury on day 5 after insult in a piglet model.
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影响因子：
2.1
作者：
Gunn AJ;Bennet L
通讯作者：
Bennet L
影响因子：
3.5
作者：
Isobe, K;Kusaka, T;Onishi, S
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Onishi, S
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Pichler, Gerhard;Binder, Corinna;Urlesberger, Berndt
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Urlesberger, Berndt
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3.6
作者：
Marks, KA;Mallard, EC;Edwards, AD
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Edwards, AD
影响因子：
3.6
作者：
Lee, Anne C. C.;Kozuki, Naoko;Blencowe, Hannah;Vos, Theo;Bahalim, Adil;Darmstadt, Gary L.;Niermeyer, Susan;Ellis, Matthew;Robertson, Nicola J.;Cousens, Simon;Lawn, Joy E.
通讯作者：
Lawn, Joy E.