Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.
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DOI：
10.1016/j.cell.2022.06.003
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发表时间：
2022-07-07
期刊：
影响因子：
64.5
通讯作者：
Stockwell, Brent R.
中科院分区：
文献类型：
--
作者：
Stockwell, Brent R.
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unanswered questions in the ferroptosis field are highlighted. The next decade promises to yield further breakthroughs in the mechanisms governing ferroptosis, and additional ways of harnessing ferroptosis for therapeutic benefit.
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